Results 51 to 60 of about 4,177,944 (282)

Recent Advances in Piezoelectric Compliant Devices for Ultrahigh-Precision Engineering

Micromachines
With advancements in small-scale research fields, precision manipulation has become crucial for interacting with small objects. As research progresses, the demand for higher precision in manipulation has led to the emergence of ultrahigh-precision ...
Zeyi Wu, Zehao Wu, I-Ming Chen, Qingsong Xu   +3 more
doaj   +1 more source

Motion error based robust topology optimization for compliant mechanisms under material dispersion and uncertain forces

, 2017
Due to the inevitable phenomena that multi-source uncertainty factors in compliant mechanisms, which generally originate from material dispersion and uncertain external forces, severely affect the output motion accuracy, the robustness assessment and ...
Geng XY, 王睿星, Wang XJ, Wang L, Shi QH, Xinyu Geng, Lei Wang, Qinghe Shi, Xiaojun Wang, Ruixing Wang   +9 more
core   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Redesign of a Balance Rehabilitation Device Based on a Parallel Continuum Mechanism

Machines
In the present work, a parallel continuum manipulator for trunk rehabilitation tasks for patients who have suffered a stroke was analyzed and redesigned.
Francisco J. Campa, Daniel Díaz-Caneja
doaj   +1 more source

Frustration propagation in tubular foldable mechanisms

Frontiers in Physics, 2023
Shell mechanisms are patterned surface-like structures with compliant deformation modes that allow them to change shape drastically. Examples include many origami and kirigami tessellations as well as other periodic truss mechanisms. The deployment paths
A. Reddy, A. Karami, H. Nassar
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Design and Analysis of the Attitude Adjustment Mechanism for a Rotor MAV Based on Compliant Mechanisms

Aerospace, 2021
Traditional swash plates generally have numerous parts, which may result in the abrasion of key parts. In this paper, to avoid the problems of traditional swash plates, a low-cost and high-reliability rotor micro-aerial vehicle integrated attitude ...
Jingjing Zhang, Jinglin Luo
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Compliant mechanisms for an active cardiac stabilizer: lessons and new requirements in the design of a novel surgical tool [PDF]

Mechanical Sciences, 2011
In this paper, three aspects of the use of compliant mechanisms for a new surgical tool, an active cardiac stabilizer, are outlined. First, the interest of compliant mechanisms in the design of the stabilizer is demonstrated with <i>in vivo</i ...
L. Rubbert, P. Renaud, W. Bachta, J. Gangloff   +3 more
doaj   +1 more source