Results 51 to 60 of about 3,496,969 (278)

Redesign of a Balance Rehabilitation Device Based on a Parallel Continuum Mechanism

Machines
In the present work, a parallel continuum manipulator for trunk rehabilitation tasks for patients who have suffered a stroke was analyzed and redesigned.
Francisco J. Campa, Daniel Díaz-Caneja
doaj   +1 more source

A function for characterizing complete kinetostatic behaviors of compliant bistable mechanisms [PDF]

Mechanical Sciences, 2014
In this paper, a straightforward and accurate numerical modeling (a rational function called "tri-root bistable function") are proposed to represent the complete nonlinear bistable force-displacement characteristics.
G. Li, G. Chen
doaj   +1 more source

Characterization of spatial parasitic motions of compliant mechanisms induced by manufacturing errors

, 2016
This paper proposes a theoretical model for characterizing manufacturing error induced spatial parasitic motions (MESPM) of compliant mechanisms (CM), and investigates the inherent statistic features of MESPM using Monte Carlo simulation. It also applies
To, S, Zhou, X, Wang, R, Zhu, Z, Zhang, X   +4 more
core   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Novel Additive Manufacturing Pneumatic Actuators and Mechanisms for Food Handling Grippers

Actuators, 2014
Conventional pneumatic grippers are widely used in industrial pick and place robot processes for rigid objects. They are simple, robust and fast, but their design, motion and features are limited, and they do not fulfil the final purpose.
Carlos Blanes, Martín Mellado, Pablo Beltran   +2 more
doaj   +1 more source

Control with a Compliant Force-Torque Sensor [PDF]

, 2012
There are assembly tasks which require a compliant device at the end-effector since possible disturbances are beyond the bandwidth of robot control. This paper discusses a compliant force-torque sensor for assembly.
Hirzinger, Gerd, Suppa, Michael, Lange, Friedrich   +2 more
core  

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Design, Fabrication, Testing and Simulation of a Rotary Double Comb Drives Actuated Microgripper

Micromachines, 2021
This paper presents the development of a new microgripper actuated by means of rotary-comb drives equipped with two cooperating fingers arrays. The microsystem presents eight CSFH flexures (Conjugate Surface Flexure Hinge) that allow the designer to ...
Nicola Pio Belfiore, Alvise Bagolini, Andrea Rossi, Gabriele Bocchetta, Federica Vurchio, Rocco Crescenzi, Andrea Scorza, Pierluigi Bellutti, Salvatore Andrea Sciuto   +8 more
doaj   +1 more source

Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone, Freddy Chafota, Miguel E. Rentería, Randi J. Hagerman, Ellery Santos, Anna Atkinson, Nicholas G. Martin, Elsdon Storey, Danuta Z. Loesch   +8 more
wiley   +1 more source