Results 51 to 60 of about 9,193,693 (296)

Scalloping and Stress Concentration in DRIE-Manufactured Comb-Drives

Actuators, 2018
In the last decades, microelectromechanical systems have been increasing their number of degrees of freedom and their structural complexity. Hence, most recently designed MEMSs have required higher mobility than in the past and higher structural strength
Silvia Bertini, Matteo Verotti, Alvise Bagolini, Pierliugi Bellutti, Giuseppe Ruta, Nicola Pio Belfiore   +5 more
doaj   +1 more source

Analysis and Optimization of Dynamic and Static Characteristics of the Compliant-Amplifying Mechanisms

Micromachines, 2023
Compliant amplifying mechanisms are used widely in high-precision instruments driven by piezoelectric actuators, and the dynamic and static characteristics of these mechanisms are closely related to instrument performance.
Jin Wang, Zijian Jing, Zongliang Xie, Zongqi Ning, Bo Qi   +4 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Redesign of a Balance Rehabilitation Device Based on a Parallel Continuum Mechanism

Machines
In the present work, a parallel continuum manipulator for trunk rehabilitation tasks for patients who have suffered a stroke was analyzed and redesigned.
Francisco J. Campa, Daniel Díaz-Caneja
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Recent Advances in Piezoelectric Compliant Devices for Ultrahigh-Precision Engineering

Micromachines
With advancements in small-scale research fields, precision manipulation has become crucial for interacting with small objects. As research progresses, the demand for higher precision in manipulation has led to the emergence of ultrahigh-precision ...
Zeyi Wu, Zehao Wu, I-Ming Chen, Qingsong Xu   +3 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

A function for characterizing complete kinetostatic behaviors of compliant bistable mechanisms [PDF]

Mechanical Sciences, 2014
In this paper, a straightforward and accurate numerical modeling (a rational function called "tri-root bistable function") are proposed to represent the complete nonlinear bistable force-displacement characteristics.
G. Li, G. Chen
doaj   +1 more source

Design and Performance of a Spatial 6-RRRR Compliant Parallel Nanopositioning Stage

Micromachines, 2022
Piezoelectric actuators (PEAs) and compliant parallel mechanisms (CPMs) are advantageous for designing nanopositioning stages (NPSs) with multiple degrees of freedom (multi-DOFs).
Ruizhou Wang, Heng Wu
doaj   +1 more source