Results 91 to 100 of about 1,173,701 (313)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

COMPOR: a Methodology, a Component Model, a Component based Framework and Tools to Build Multiagent Systems

CLEI Electronic Journal, 2004
In this paper a set of guidelines, techniques and tools to develop software for multiagent systems (MAS), named COMPOR, are introduced. The main objetive is to provide an effective approach to deal with the dynamic and openness characteristics of such ...
Hyggo Oliveira de Almeira, Evandro de Barros Costa, Rodrigo de Barros Paes, Angelo Percusich   +3 more
doaj   +1 more source

Built-in contract testing in component-based application engineering

, 2022
S.87-100 : Ill., Lit.Assembling new software systems from prefabricated components is an attractive alternative to traditional software engineering practices and promises to increase reuse and reduce development costs.
Groß, H.-G.
core  

Semantic model-driven architecting of service-based software systems [PDF]

, 2007
Model-driven development is a software development framework that emphasises model-based abstraction and automated code generation. Service-based software architectures benefit in particular from semantic, ontology-based modelling.
Claus Pahl, Pahl, Claus
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Principles of UML-based component modeling

, 2022
S.70-85 : Ill., Lit.With the proliferation of middleware technologies and component infrastructures, there is a growing need to support high-level, platform.independent ways of modeling components and component-based systems.
Bunse, C., Kamsties, E., Zettel, J., Atkinson, C.   +3 more
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Algebraic specifications and refinement for component-based development using RAISE

Journal of Computer Science and Technology, 2002
There are two main activities in Component-Based Development: component development, where we build libraries for general use, and component integration, where we assemble an application from existing components.
Elsa Clara Estévez, Pablo Rubén Fillottrani   +1 more
doaj  

Component-based model-driven software development.

, 2011
Model-driven software development (MDSD) and component-based software development are both paradigms for reducing complexity and for increasing abstraction and reuse in software development. In this thesis, we aim at combining the advantages of each by introducing methods from component-based development into MDSD.
openaire   +3 more sources

Software component certification

, 2001
A model for software component certification based on test certificates supplied by developers in a standard portable form is proposed. Purchasers are expected to use the model to determine the quality and suitability of purchased software.
Morris, J., Lee, G., Bundell, G.A., Lam, C.P., Parker, K.   +4 more
core