Results 61 to 70 of about 1,173,701 (313)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Driving component-based software development through quality modelling
, 2022 S.207-224 : Ill., Lit.With the advent of the OMG's new Model Driven Architecture (MDA), and the growing uptake of the UML, the concept of model-driven development is receiving increasing attention.
Bunse, C., Wüst, J., Atkinson, C.
core
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
A Component-Oriented Programming for Embedded Mobile Robot Software
International Journal of Advanced Robotic Systems, 2008 Applying software reuse to many Embedded Real-Time (ERT) systems poses significant challenges to industrial software processes due to the resource-constrained and real-time requirements of the systems.
Safaai Deris +2 more
doaj
Attribute based component design: Supporting model driven development in CbSE [PDF]
, 2007 In analysing the evolution of Software Engineering, the scale of the components has increased, the requirements for different domains become complex and a variety of different component frameworks and their associated models have emerged.
Kyaw, Phyo
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Software Product Line Reengineering: A Case Study on the Geographic Domain
Journal of Computer Science and Technology, 2016 The growing adoption of software product lines (SPL) represents perhaps a paradigm shift in software development aiming at improving cost, quality, time to market, and developer productivity.
Agustina Buccella +3 more
doaj
Applying of component system development in object methodology
Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2013 In the last three decades, the concept and implementation of component-based architectures have been promoted in software systems creation. Increasingly complex demands are placed on the software component systems, in particular relating to the dynamic ...
Milan Mišovič, Oldřich Faldík
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source