Results 141 to 150 of about 394,134 (317)

The SATIN component system - a metamodel for engineering adaptable mobile systems

, 2006
Mobile computing devices, such as personal digital assistants and mobile phones, are becoming increasingly popular, smaller, and more capable. We argue that mobile systems should be able to adapt to changing requirements and execution environments ...
Zachariadis, S., Mascolo, C., Emmerich, W.   +2 more
core  

Pattern-based software architecture for service-oriented software systems [PDF]

, 2010
Service-oriented architecture is a recent conceptual framework for service-oriented software platforms. Architectures are of great importance for the evolution of software systems.
Pahl, Claus, Barrett, Ronan
core  

Architecture-based fault tolerance support for grid applications

, 2011
Failure in long running grid applications is arguably inevitable and costly. Therefore, fault tolerance (FT) support for grid applications is needed.
Heinz W. Schmidt, Schmidt, Heinz,, Ian D. Peake, Iman I. Yusuf, Peake, Ian,, I Yusuf, Iman,   +5 more
core   +1 more source

Connecting basal body and mitochondrial DNA: TAC53 and the tubular organization of the tripartite attachment complex.

PLoS Pathogens
The Tripartite Attachment Complex (TAC) is essential for mitochondrial DNA (kDNA) segregation in Trypanosoma brucei, providing a physical link between the flagellar basal body and the mitochondrial genome.
Clirim Jetishi, Salome Aeschlimann, Bernd Schimanski, Sandro Käser, Rachel Mullner, Silke Oeljeklaus, Bungo Akiyoshi, Bettina Warscheid, Falk Butter, André Schneider, Torsten Ochsenreiter   +10 more
doaj   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Distributed component technologies and their software engineering implications

, 2002
In this state of the art report, we review advances in distributed component technologies, such as the Enterprise Java Beans specification and the CORBA Component Model. We assess the state of industrial practice in the use of distributed components.
Wolfgang Emmerich, Emmerich, W
core   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

When does the mirror get misted? How the rate of component change and product complexity impact the mirroring hypothesis

, 2015
The mirroring hypothesis – the assumed architectural mapping between firms’ strategic choices of product architecture and firm architecture, and between firms’ architectural choices and the industry structures – is a central theme within modularity ...
Burton, Nicholas
core