Results 141 to 150 of about 995,298 (311)

Component-Based Software Engineering. The KobrA Approach

, 2022
S.247-252 : Ill., Lit.The software industry is pinning its hopes for future software productivity and quality gains on component-based development. However, to date the component paradigm has only really penetrated the "implementation" phase of the ...
Bunse, C., Bayer, J., Muthig, D., Kamsties, E., Wüst, J., Zettel, J., Laitenberger, O., Laqua, R., Atkinson, C., Paech, B.   +9 more
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

A globally-applied component model for programmable networking

, 2003
We argue that currently developed software frameworks for active and programmable networking do not provide a truly generic approach to the development, deployment, and management of services.
Kevin Lee, Blair, Gordon, Lee, K, Blair, GS, Blair, G.S., Gomes, A.T., Schmid, S, Joolia, A, Ackbar Joolia, J ó Ueyama, Geoff Coulson, Schmid, S., Lee, K., Stefan Schmid, Antônio T. Gomes, Gomes, A T, Joolia, A., Gordon S. Blair, Coulson, G., Ueyama, J., Gomes, AT, Ueyama, J, Coulson, G   +22 more
core   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Domain specific modeling approach for component-based software development

, 2009
Related work -- Component composition -- Domain-specific modeling -- Model-based component composition environment for a specific domain -- Mobile service creation framework (MCSF) -- A model-driven approach to implementing dependable component-based ...
Yang, Zhihui.
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

A component-based method for developing web applications

Revista Colombiana de Computación, 2003
We describe, in this paper, a component-based software engineering method for helping development teams to plan, organize, control, and develop web applications.
Jonas A. Montilva C., Judith Barrios A.
doaj  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

A domain-specific language based approach to component composition, error-detection, and fault prediction [PDF]

, 2001
Current methods of software production are resource-intensive and often require a number of highly skilled professionals. To develop a well-designed and effectively implemented system requires a large investment of resources, often numbering into ...
Ingham, James, Ingham, J.
core  

ADESSO. Scientific Software Development Environment

Journal of Computer Science and Technology, 2003
This paper presents the Adesso, a computational environment for the development of scientific software. The Adesso environment leverages the reusable software component programming model to support the development and integration of components to several
Rubens C. Machado, Andre V. Saude, Roberto Lotufo, Alexandre G. Silva   +3 more
doaj