Results 101 to 110 of about 1,301,914 (340)

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Nonlinear Normal Modes of a Rotating Shaft Based on the Invariant Manifold Method

International Journal of Rotating Machinery, 2004
The nonlinear normal mode methodology is generalized to the study of a rotating shaft supported by two short journal bearings. For rotating shafts, nonlinearities are generated by forces arising from the supporting hydraulic bearings.
Mathias Legrand, Dongying Jiang, Christophe Pierre, Steven W. Shaw   +3 more
doaj   +1 more source

Multibody dynamics: Modeling component flexibility with fixed, free, loaded, constraint, and residual modes [PDF]

The assumed-modes method in multibody dynamics allows the elastic deformation of each component in the system to be approximated by a sum of products of spatial and temporal functions commonly known as modes and modal coordinates respectively. The choice
Spanos, John T., Tsuha, Walter S.
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Implementation of the block-Krylov boundary flexibility method of component synthesis [PDF]

A method of dynamic substructuring is presented which utilizes a set of static Ritz vectors as a replacement for normal eigenvectors in component mode synthesis.
Abdallah, Ayman A., Carney, Kelly S., Hucklebridge, Arthur A.   +2 more
core   +1 more source

Deviatoric component modes in an interval component mode synthesis procedure

, 2008
This paper focuses on the integration of interval uncertainties in the procedure of the Component Mode Synthesis (CMS) method used for the dynamic analysis of large finite element (FE) models in mechanical engineering. Two methods are combined in this work: the Interval Finite Element Method for the nondeterministic eigenvalue and frequency response ...
De Gersem, Hilde, Moens, David, Desmet, Wim, Vandepitte, Dirk   +3 more
openaire   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Dynamic substructuring for shock spectrum analysis using component mode synthesis [PDF]

Component mode synthesis was used to analyze different types of structures with MSC NASTRAN. The theory and technique of using Multipoint Constraint Equations (MPCs) to connect substructures to each other or to a common foundation is presented ...
Bogert, Philip B., Lev, Avivi, Mcpheeters, Barton W., Scavuzzo, Rudolph J.   +3 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

High-speed tracked vehicle model order reduction for static and dynamic simulations

Defence Technology
In this paper, a model order reduction strategy is adopted for the static and dynamic behaviour simulation of a high-speed tracked vehicle. The total number of degree of freedom of the structure is condensed through a selection of interface degrees of ...
Luca Dimauro, Simone Venturini, Antonio Tota, Enrico Galvagno, Mauro Velardocchia   +4 more
doaj   +1 more source