Results 111 to 120 of about 1,301,914 (340)

Parametric optimization with the use of numerically efficient finite element models

open access: yesAdvances in Mechanical Engineering, 2015
This article presents numerically efficient computational models for solving exemplary problems of parametric optimization with the use of the finite element method.
Piotr Danielczyk
doaj   +1 more source

A Novel Image Fusion Framework Based on Sparse Representation and Pulse Coupled Neural Network

open access: yesIEEE Access, 2019
Image fusion techniques are applied to the synthesis of two or more images captured in the same scene to obtain a high-quality image. However, most of the existing fusion algorithms are aimed at single-mode images.
Li Yin   +5 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Application of the mode-shape expansion based on model order reduction methods to a composite structure

open access: yesOpen Engineering, 2017
The application of different mode-shape expansion (MSE) methods to a CFRP based on model order reduction (MOR) and component mode synthesis (CMS) methods is evaluated combining the updated stiffness parameters of the full FE model obtained with a mix ...
Fuentes Humberto Peredo
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Hierarchical tapered bar elements undergoing axial deformation [PDF]

open access: yes
A method is described to model the dynamics of tapered axial bars of various cross sections based on the well-known Craig/Bampton component mode synthesis technique.
Ganesan, N., Thampi, S. K.
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Component mode synthesis and large deflection vibration of complex structures. Volume 3: Multiple-mode nonlinear free and forced vibrations of beams using finite element method [PDF]

open access: yes
Multiple-mode nonlinear forced vibration of a beam was analyzed by the finite element method. Inplane (longitudinal) displacement and inertia (IDI) are considered in the formulation.
Mei, Chuh, Shen, Mo-How
core   +1 more source

Cavity-enhanced single frequency synthesis via DFG of mode-locked pulse trains

open access: yes, 2005
We show how to synthesize a CW, single-frequency optical field from the frequency-dispersed, pulsed field of a mode-locked laser. This process, which relies on difference frequency generation in an optical cavity, is efficient and can be considered as an
Cundiff   +17 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

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