Results 161 to 170 of about 2,013,324 (312)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Neural auditory encoding and performance in speech-in-noise perception: a pilot study. [PDF]

Codas
Lucera MH, Lunardelo PP, Simões HO, Zanchetta S.   +3 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

[Controversies in primary care: Use of beta-blockers after acute myocardial infarction]. [PDF]

Aten Primaria
Fransi Galiana L, Obaya Rebollar JC, Domingo Teixidor M.   +2 more
europepmc   +1 more source

Componentes CORBA [PDF]

, 2015
openaire   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

[Teratoid Wilms tumor in an adult: A case report]. [PDF]

Rev Med Inst Mex Seguro Soc
Hernández-Marchena YN, González-Medina WE, Bolado-García PB, Surur-Zaibak EE, Balderas YO, Hernández-Valadez OF, Marrufo-Solís V, Luna HDL, García-Saury K, Méndez-Gutierrez J.   +9 more
europepmc   +1 more source

Mercados laborales y apoyo del ingreso: ¿Qué hemos aprendido de las crisis? [PDF]

(Disponible en idioma inglés únicamente) La adopción de programas de empleo de emergencia y capacitación a corto plazo para dar apoyo a los ingresos de la población afectada por episodios de inestabilidad económica desde 1995 revela el fracaso de los ...
Gustavo Márquez
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

[Instability Prevention and Treatment in Total Hip Replacement]. [PDF]

Rev Bras Ortop (Sao Paulo)
Rudelli BA, Yamaguchi FSM, Rudelli M, Oliveira LT, Miyahara HS, Gurgel HMC.   +5 more
europepmc   +1 more source