Results 151 to 160 of about 2,013,324 (312)
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Propuesta de indicadores para gestión del capital estructural en grupos de investigación.
Universidad y Empresa, 2013 La gestión del capital intelectual es hoy uno de los aspectos en los cuales las organizaciones centran su atención, por la necesidad de aplicarlo en el campo administrativo, que está compuesto por el capital estructural, humano y relacional.
Eduardo Carrillo Zambrano +2 more
doaj
VASELFCARE – Componentes gráficas
, 2019 A tecnologia tem vindo a evoluir a passos largos, trazendo bastantes benefícios para a Humanidade, sento esta actualmente aplicada em diversos âmbitos do dia a dia, como a educação, a saúde, a gestão, entre outros. A utilização desta vertente na área da saúde, mais particularmente nos cuidados de saúde, torna-se uma mais valia para a prevenção e ...
openaire +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Didasc@lia: didáctica y educación, 2012 En el artículo se realiza un análisis de la evolución que ha The article makes an analysis of the evolution experienced by the various interpretations which can be steeped in history teaching.
Francisco Felino Riverón Morales +1 more
doaj
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Cortical auditory evoked potential with different speech stimuli in children with asymptomatic congenital cytomegalovirus infection. [PDF]
CodasMadeira LR, Lunardelo PP, Tavares AR.
europepmc +1 more source