Results 41 to 50 of about 1,861,033 (245)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

The behaviour of steel and composite beam-to-column connections in fire. [PDF]

, 1999
Recent fire tests on the Cardington full-scale test frame and observations from real fires have demonstrated the significance of connections in fire, when they can have beneficial effects on the survival time of the structure. The
Al-Jabri, Khalifa Saif
core   +5 more sources

Experimental study on the effect of partial shear studs layout on flexural behavior of steel-concrete composite beams

Results in Engineering
In steel-concrete composite beams, partial shear connection offers advantages including greater ductility and lower cost. However, partial shear connection constraints on composite beam structural performance, such as reduced beam stiffness, increased ...
Amanyire Barozi Victoire, John Nyiro Mwero, Naftary Gathimba   +2 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Vibration and buckling of cross-ply composite beams using refined shear deformation theory [PDF]

, 2012
Vibration and buckling analysis of cross-ply composite beams using refined shear deformation theory is presented. The theory accounts for the parabolical variation of shear strains through the depth of beam.
Inam, Fawad, Vo, Thuc
core  

Localization of a delamination and estimation of its length in a composite laminate beam by the VSHM and pattern recognition methods [PDF]

, 2010
The focus of this work is to investigate the delamination damage in laminate composite beams, to fix a Vibration-based structural health monitoring (VSHM) method for the laminate structures.
Palazzetti, Roberto, Zucchelli, Andrea, Trendafilova, Irina, R. Palazzetti, Minak, Giangiacomo, A. Zucchelli, G. Minak, I. Trendafilova   +7 more
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Dynamic characteristics analysis of a multi-layer cantilever beam-type rotational piezoelectric energy harvester based on the Timoshenko beam model

AIP Advances
This paper presents a rotational piezoelectric energy harvester (RPVEH) based on the Timoshenko beam model. The system comprises a five-layer composite cantilever beam with a tip magnet and two external magnets, creating a tri-stable potential energy ...
Dawei Man, Qiuyu Sun, Liping Tang, Qinghu Xu, Leiyu Chen, Tingting Han   +5 more
doaj   +1 more source

Inelastic Strength for Fire Resistance of Composite I-Beam Covered by Insulation Material Subjected to Basic Loading Condition

Metals, 2021
This paper presents a nonlinear numerical study on the moment resistance of composite steel-concrete beam using fire insulation subjected to various fire scenarios and basic loading conditions.
Xuan Tung Nguyen, Jong Sup Park
doaj   +1 more source