Results 41 to 50 of about 5,214,614 (337)

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

On Isospectral Composite Beams

open access: yesApplied Sciences, 2023
We consider a composite system consisting of two identical straight elastic beams under longitudinal vibration connected by an elastic interface capable of counteracting the relative vibration of the two beams with its shearing stiffness. We construct examples of isospectral composite beams, i.e., countable one-parameter families of beams having ...
Alexandre Kawano, Antonino Morassi
openaire   +2 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

Geometrical nonlinear analysis of thin-walled composite beams using finite element method based on first order shear deformation theory [PDF]

open access: yes, 2011
Based on a seven-degree-of-freedom shear deformable beam model, a geometrical nonlinear analysis of thin-walled composite beams with arbitrary lay-ups under various types of loads is presented.
Lee, Jaehong, Vo, Thuc
core   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

open access: yesFEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell   +2 more
wiley   +1 more source

The influence of acrylate triblock copolymer embedded in matrix on composite structures’ responses to low-velocity impacts [PDF]

open access: yes, 2012
In passive safety structures the use of composite materials has increased significantly recently due to their low specific mass and high energy absorption capacities.
Frédéric Leonardi   +7 more
core   +1 more source

Experimental study on the effect of partial shear studs layout on flexural behavior of steel-concrete composite beams

open access: yesResults in Engineering
In steel-concrete composite beams, partial shear connection offers advantages including greater ductility and lower cost. However, partial shear connection constraints on composite beam structural performance, such as reduced beam stiffness, increased ...
Amanyire Barozi Victoire   +2 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Dynamic characteristics analysis of a multi-layer cantilever beam-type rotational piezoelectric energy harvester based on the Timoshenko beam model

open access: yesAIP Advances
This paper presents a rotational piezoelectric energy harvester (RPVEH) based on the Timoshenko beam model. The system comprises a five-layer composite cantilever beam with a tip magnet and two external magnets, creating a tri-stable potential energy ...
Dawei Man   +5 more
doaj   +1 more source

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