Results 51 to 60 of about 3,058,734 (312)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Efficiency of artificial neural networks in determining scour depth at composite bridge piers

International Journal of River Basin Management, 2019
Scouring is the most common cause of bridge failure. This study was conducted to evaluate the efficiency of the Artificial Neural Networks (ANN) in determining scour depth around composite bridge piers.
A. Amini, Shahriar Hamidi, A. Shirzadi, J. Behmanesh, Shatirah Akib   +4 more
semanticscholar   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Fire behavior of composite steel truss bridge girders: numerical investigation and design strategies

Advances in Bridge Engineering
Fire pose more severe threat to steel truss bridge girders as compared to common steel plate and box bridge girders. To deeply clarify failure mechanism of fire exposed steel truss bridge girders, this paper presents an investigation on fire performance ...
Gang Zhang, Zhuoya Yuan, Yuhang Ding, Feng Xu, Chenhao Tang, Shichao Wang   +5 more
doaj   +1 more source

Bending performance of prefabricated ultra-thin UHPC unit plate reinforced orthotropic steel bridge decks

Frontiers in Materials
To address the challenges related to lengthy construction period, complex maintenance requirement, and the elevated risk of shrinkage cracking associated with cast-in-place UHPC reinforcement of orthotropic steel bridge decks. This paper proposes a novel
Xiang Zhou, Xiang Zhou, Jinlong Jiang, Jinlong Jiang, Le Liu, Le Liu, Shan Wang, Shan Wang, Xilei Deng, Xilei Deng, Yong Li, Yong Li, Zhongya Zhang, Zhongya Zhang   +13 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Numerical study of pedestrian suspension bridge with innovative composite deck

Heliyon, 2020
The increasing trend of using light and slender deck in pedestrian bridge has raised the issue of instability under pedestrian movement. The suspension pedestrian bridges are more vulnerable as lateral vibration often occurred in such type of bridges ...
Saima Ali, David Thambiratnam, Xuemei Liu, Sabrina Fawzia   +3 more
doaj   +1 more source

Influence of local deck vibrations on the evaluation of the maximum acceleration of a steel-concrete composite bridge for a high-speed railway

, 2019
European design standards have established an upper limit on the deck acceleration of the high-speed railway bridges, however the influence of local vibrations of the deck members is rarely considered when modelling the vibrational responses of bridges ...
K. Matsuoka, A. Collina, C. Somaschini, M. Sogabe   +3 more
semanticscholar   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source