Results 61 to 70 of about 3,058,734 (312)
Applied SciencesSteel–concrete composite girder rigid frame bridges with V-shaped piers are a new type of bridge structure. Based on the traditional composite continuous beam bridge, part or all of the vertical piers are changed into V-shaped piers.
Yong Zeng +3 more
doaj +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Endurance of the wooden bridge reinforced by the dowel plates
Studia Geotechnica et Mechanica, 2018 The most important piece of road infrastructure is bridges. Wooden bridges have advanced constantly during the past decades. The trend began in Scandinavian countries but has also now gained significant ground in Russia.
Dahoua Lamri, Boymatov Fakhridine
doaj +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Advances in Materials Science and Engineering, 2018 In order to extend the understanding of structural performance of a T-rib glass fibre-reinforced polymer (GFRP) plate-concrete composite bridge deck, four GFRP plate-concrete composite bridge decks were tested, which consist of cast-in-place concrete ...
Jun Tian +4 more
semanticscholar +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Research of Steel-Concrete Composite Bridge under Blasting Loads
Advance in Civil Engineering, 2018 This paper presents a study to simulate the performance of steel-plate composite bridge under various blasting loads. The multi-Euler domain method based on the fully coupled Lagrange and Euler models is adopted for the structural analysis of explosion ...
Yuan Li, Shuanhai He
semanticscholar +1 more source