Lightweight metallic matrix composites. Development of new composites material reinforced with carbon structures [PDF]
, 2019 Carbon nano/micro-structures used as fillers in metallic lightweight alloys matrix composites are receiving considerable attention in scientific research and industrial applications.
Genova, Virgilio +5 more
core +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Surface modification of Ti alloys with WC-TiB2-reinforced laser composite coatings
Science and Engineering of Composite Materials, 2016 Laser cladding of the TiAl/Fe+Co-coated WC+TiB2 pre-placed mixed powders on a Ti-6Al-4V alloy substrate can be used to form TiB2/α-W2C-reinforced composite coating, which improved the wear resistance of the substrate.
Li Jianing +5 more
doaj +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Microstructure and Properties of Electro-brush Plating Ni-graphene Composite Coating
Cailiao gongcheng, 2018 Ni-graphene composite coating was prepared on 45 steel substrates by electro-brush plating. The graphene layers,graphene in the composite coatings,the grain size and morphology of the coatings were characterized by transmission electron microscope(TEM ...
DING Xiao-long +4 more
doaj +1 more source
Development of nickel phosphorus coatings containing micro particles of talc phyllosilicates [PDF]
, 2013 The present work aims to characterized nickel phosphorus coatings co-deposited with talc particles on steel. The NiP-talc composite deposits were developed to serve as hard coatings with a lubricating effect at 600 C.
Alexis, Joël +3 more
core +3 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Intergranular metal phase increases thermal shock resistance of ceramic coating [PDF]
, 1966 Dispersed copper phase increases the thermal shock resistance of a plasma-arc-sprayed coating of zirconia used as a heat barrier on a metal substrate. A small amount of copper is deposited on the granules of the zirconia powder before arc-spraying the ...
Carpenter, H. W.
core +1 more source
The sol–gel route: A versatile process for up-scaling the fabrication of gas-tight thin electrolyte layers [PDF]
, 2011 Sol–gel routes are often investigated and adapted to prepare, by suitable chemical modifications, submicronic powders and derived materials with controlled morphology, which cannot be obtained by conventional solid state chemistry paths.
Ansart, Florence +5 more
core +4 more sources
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source