Results 101 to 110 of about 50,371 (314)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Finite element analysis of concrete-encased steel composite columns with off-center steel section [PDF]

, 2018
[EN] Concrete encased steel composite columns have been widely used in high-rise buildings and top-down constructions owning to excellent load-carrying capacity and fire resistance.
Liew, Jat Yuen, Li, Shan, Lai, Binglin
core   +1 more source

Mechanical Properties of Full-Scale UHPC-Filled Steel Tube Composite Columns under Axial Load. [PDF]

Materials (Basel), 2023
Cheng B, Wang W, Wang W, Li J, Huang J, Chen H.   +5 more
europepmc   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Experimental behaviour of RC shear walls framed with steel reinforced concrete (SRC) columns under cyclic loading

, 2010
This paper focuses on the seismic behaviour of composite shear walls which are RC shear walls framed with steel reinforced concrete (SRC) columns. Six shear wall models, including three RC shear walls framed with SRC columns and three framed with RC ...
Han, Lin-Hai, Liao, Fei-Yu, Tao, Zhong (R12091)   +2 more
core  

Experimental Study and Numerical Analysis of the Seismic Performance of Glass-Fiber Reinforced Plastic Tube Ultra-High Performance Concrete Composite Columns. [PDF]

Materials (Basel), 2023
Tan X, Zhu M, Liu W.
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Differential axial shortening and its effects in high rise buildings with composite concrete filled tube columns

, 2017
Use of concrete filled steel tube columns is becoming increasingly popular in high rise buildings due to their composite action, superior strength, seismic and fire resistance capacities and construction simplicity.
Samarakkody, Dilrukshie I., Dilrukshie I. Samarakkody, David P. Thambiratnam, Chan, Tommy H.T., Moragaspitiya, Praveen H.N., Praveen H.N. Moragaspitiya, Thambiratnam, David P., Tommy H.T. Chan   +7 more
core   +1 more source

Axial Compression Behavior of Elliptical Concrete-Filled Steel Tube Composite Short Columns with Encased Steel Considering Spherical-Cap Gap

Buildings
This study explored the axial compression behavior of elliptical concrete-filled steel tubes with encased steel considering spherical-cap gap (GSECFST) composite short columns.
Liangqin Jiang, Liang Ma, Xiaomeng Hou, Jing Ji, Huiling Zhang, Zhanbin Zhang, Yuan Liang, Xuan Chu   +7 more
doaj   +1 more source

Comparison of Failure for Thin-Walled Composite Columns. [PDF]

Materials (Basel), 2021
Rozylo P.
europepmc   +1 more source