Results 181 to 190 of about 5,973,949 (247)

Advancing Pregnancy and Pediatric Science through the NIH Transporter Elucidation Network

Clinical Pharmacology &Therapeutics, EarlyView.
Human gestation is characterized by dynamic changes in maternal physiology and maturation of tissue functions before and after birth. The fetus and neonate are highly dependent upon transfer of maternal nutrients via the placenta and lactating mammary gland, which frequently involve selective membrane transporter proteins.
Joanne Wang, Jashvant D Unadkat, Samuel LM Arnold, John K Fallon, Pouria Fattahi, Dan Dongeun Huh, Nicholas Ieronimakis, Edward J Kelly, Svetlana Lutsenko, Robert M Stroud, Jacqueline B Tiley, Jia Yang, Xujia Zhou, Hao Zhu, Rajini Rao, Kathleen M Giacomini, Lauren M Aleksunes   +16 more
wiley   +1 more source

Composite dietary antioxidant index and risk of ischemic heart disease and stroke: insights from a UK Biobank large-scale cohort study. [PDF]

Front Nutr
Xu SY, Liu HY, Chen LH, Lu XX, Hang FJ, Zhao LY.   +5 more
europepmc   +1 more source

Transforming Growth Factor‐β (TGF‐β)–Dependent Iron Homeostasis and Altered TGF‐β Responsiveness in FLVCR1‐Deficient CD4 T Cells

Barrier Immunity, EarlyView.
Negative feedback resulting from continuous TGFβRI expression in FLVCR1‐deficient CD4 T cells. Unlike in normal CD4 T cells, TGF‐βRI is not degraded upon activation in FLVCR1‐deficient CD4 T cells. Sustained receptor expression results in increased TGF‐β, leading to dysregulated iron homeostasis, impaired cell proliferation, and enhanced cell death ...
Amber L. Siglin, Zelong Han, Afia Nkansah, Cheong‐Hee Chang   +3 more
wiley   +1 more source

Membrane lipid metabolism as a regulatory frontier in neural crest biology: Roles for sphingolipids, cholesterol, and lipid rafts

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are multipotent, migratory stem‐like cells essential for vertebrate development that contribute broadly to many tissues including the craniofacial skeleton, peripheral nervous system, and pigment‐producing cells. Their development progresses through phases of induction, specification, delamination, migration, and ...
Allison E. Mancini, Mallorie P. Jenne, Michael L. Piacentino   +2 more
wiley   +1 more source

The association of the composite dietary antioxidant index with the risk of cardiometabolic disorders: findings from the Tehran Lipid and Glucose Study. [PDF]

J Health Popul Nutr
Ahmadirad H, Farhadnejad H, Saber N, Jahromi MK, Teymoori F, Mirmiran P, Azizi F.   +6 more
europepmc   +1 more source

Role of selenium in the pathophysiology of cardiorenal anaemia syndrome

ESC Heart Failure, Volume 12, Issue 2, Page 770-780, April 2025.
Abstract Chronic kidney disease (CKD) and cardiovascular disease (CVD) have multiple bidirectional mechanisms, and anaemia is one of the critical factors that are associated with the progression of the two disorders [referred to as cardiorenal anaemia syndrome (CRAS)].
Shigeyuki Arai, Minoru Yasukawa, Shigeru Shibata   +2 more
wiley   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Association of composite dietary antioxidant index with incidence and mortality of aortic aneurysm and dissection: insights from the UK Biobank. [PDF]

Front Nutr
Lai S, Qin H, Liu M, Lai Z, Ji S, Rong D, Guo W.   +6 more
europepmc   +1 more source

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

Associations of Frailty Index and Composite Dietary Antioxidant Index With Major Ocular Diseases and Analysis of Component Contributions: A Cross-Sectional Study. [PDF]

Transl Vis Sci Technol
Ju H, Jin L, Qin X, Tian Y, Peng H, Wang X.   +5 more
europepmc   +1 more source