Results 181 to 190 of about 11,353,979 (422)

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan   +10 more
wiley   +1 more source

Engineered mycelium composite construction materials from fungal biorefineries: A critical review

open access: yesMaterials & Design, 2020
Mycelium composites are an emerging class of cheap and environmentally sustainable materials experiencing increasing research interest and commercialisation in the EU and USA for construction applications. These materials utilise natural fungal growth as
Mitchell Jones   +4 more
doaj  

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

open access: yesMolecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim   +8 more
wiley   +1 more source

Comparison of dynamic fatigue behavior between SiC whisker-reinforced composite and monolithic silicon nitrides [PDF]

open access: yes
The dynamic fatigue behavior of 30 vol percent silicon nitride whisker-reinforced composite and monolithic silicon nitrides were determined as a function of temperature from 1100 to 1300 C in ambient air.
Choi, Sung R., Salem, Jonathan A.
core   +1 more source

Composites materials

open access: yes, 2012
El proyecto fin de carrera trata sobre los materiales compuestos, explicando detalladamente su composición, clasificación y su comportamiento mecánico.
openaire   +2 more sources

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

open access: yesMolecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka   +10 more
wiley   +1 more source

Accelerating Surface Composition Characterization of Thin-Film Materials Libraries using Multi-Output Gaussian Process Regression [PDF]

open access: yesarXiv
Efficient characterization of surface compositions across high-dimensional materials spaces is critical for accelerating the discovery of surface-dominated functional materials. While X-ray photoelectron spectroscopy allows detailed surface composition investigation, it remains a time-intensive technique.
arxiv  

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