Results 161 to 170 of about 549,019 (312)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

The Influence of Composition and Technology on the Properties of Composite Material Based on Scrap Tires and Polymer Binder

open access: yes
The presented work is dedicated to the examination of effect of hardening temperature and composition on the mechanical properties of composite material made from mechanically grinded scrap tires and polyurethane type binder with different reactivity ...
Mālers, Laimonis   +2 more
core  

Composite Materials (II)

open access: yesJournal of the Society of Materials Science, Japan, 1975
openaire   +3 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Correlation between Composition and Properties of Composite Material Based on Scrap Tires

open access: yes
Purpose of present work is to investigate mechanical and insulation properties of the composite material based on scrap tires and polyurethane-type binder in correlation with composition of composite material. The studies of material’s hardness must be
Mālers, Laimonis   +3 more
core  

Composite materials [PDF]

open access: yesZavarivanje i zavarene konstrukcije, 2016
openaire   +2 more sources

Investigation of Ag-ZnO/rGO Hybrid Composite Material as a Photocatalyst for Phenol Degradation in Aqueous Systems. [PDF]

open access: yesACS Omega
Imboon T   +7 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

Silkfibroin-Ca-P composite bone replacement material for guided bone growth

open access: yes, 2015
Mineralized natural protein based materials are investigated as novel materials to be used in tissue engineering and as bone replacement materials.

core  

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