Results 51 to 60 of about 11,526,878 (396)

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Effect of hydrostatic pressure on the anodic dissolution process of X80 steel

Journal of Materials Research and Technology
Based on the fact that hydrostatic pressure affects chemical potentials of reaction species and the structure evolution of electric double layer (EDL), the authors propose a generalized-BV equation to analyze the anodic dissolution process of X80 steel ...
Shixiong Wu, Zhiming Gao, Hang Jia, Jialiang Liu, Wenbin Hu   +4 more
doaj   +1 more source

Atomic simulations on the deformation mechanisms in nano-crystalline Ni–Al series Ni-based superalloy based on grain size, strain rate and temperature

Journal of Materials Research and Technology, 2023
Molecular Dynamic (MD) simulations were used to investigate the tensile properties of nanocrystalline Ni–Al series Ni-based superalloy at different grain sizes (6.54–20 nm), strain rates (1 × 107–5 × 108 s−1) and temperatures (300–1000 K).
Huicong Dong, Tianhao Xu, Tianyang Ning, Meng Liu, Dayong Wu, Haikun Ma, Zhihao Feng, Balaji Narayanaswamy, Ru Su, Tao Wang   +9 more
doaj   +1 more source

Process for application of powder particles to filamentary materials [PDF]

, 1991
This invention is a process for the uniform application of polymer powder particles to a filamentary material in a continuous manner to form a uniform composite prepreg material. A tow of the filamentary material is fed under carefully controlled tension
Baucom, Robert M., Marchello, Joseph M., Snoha, John J.   +2 more
core   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

Assessing shear, tensile and fracture properties of macroporous nanocomposites using the Arcan test

Polymer Testing, 2022
Macroporous polymers and nanocomposites remain popular materials due to their low densities and unique interconnected pore structures. The determination of mechanical properties in relevant loading conditions, such as shear, remains largely underexplored
Ranting Wu, Mitchell P. Jones, Qixiang Jiang, John M. Hodgkinson, Angelika Menner, Alexander Bismarck   +5 more
doaj   +1 more source

Fatigue crack growth in a particulate TiB2 reinforced powder metallurgy iron-based composite

, 2003
Fatigue crack growth behavior has been examined in a particulate titanium diboride (TiB2)–reinforced iron-based composite that had been produced via a mechanical alloying process.
Sinclair, I., Yang, N.
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

RGD peptide modified RBC membrane functionalized biomimetic nanoparticles for thrombolytic therapy

Journal of Materials Science: Materials in Medicine, 2023
In recent years, the fabrication of nano-drug delivery systems for targeted treatment of thrombus has become a research hotspot. In this study, we intend to construct a biomimetic nanomedicine for targeted thrombus treatment.
Zichen Xu, Jinxia Huang, Tao Zhang, Wenfeng Xu, Xiaoling Liao, Yi Wang, Guixue Wang   +6 more
doaj   +1 more source

Ultra-high gas barrier and enhanced mechanical properties of corn cellulose nanocomposite films filled with graphene oxide nanosheets

Carbohydrate Polymer Technologies and Applications, 2021
A facile and environmentally friendly route has been put forward for fabricating regenerated cellulose-based composite films (RC) with graphene oxide addition (GO).
Dongdong Qin, Xiaozhen Ma, Bao Zhang, Qing Luo, Haining Na, Jing Chen, Jin Zhu   +6 more
doaj   +1 more source