Results 101 to 110 of about 3,916,940 (335)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Nonlinear Dynamics of the High-Speed Rotating Plate

International Journal of Aerospace Engineering, 2018
High speed rotating blades are crucial components of modern large aircraft engines. The rotating blades under working condition frequently suffer from the aerodynamic, elastic and inertia loads, which may lead to large amplitude nonlinear oscillations ...
Minghui Yao, Li Ma, Wei Zhang
doaj   +1 more source

Quantization of Lie-Poisson structures by peripheric chains

, 2002
The quantization properties of composite peripheric twists are studied. Peripheric chains of extended twists are constructed for U(sl(N)) in order to obtain composite twists with sufficiently large carrier subalgebras.
Aizawa N, Ananikian D N, Celeghini E, Chari V, Drinfeld V G, Foerster A, Gómez C, Kulish P P, Lyakhovsky V D, Lyakhovsky V D, Mariano A del Olmo, Ogievetsky O V, Reshetikhin N Yu, Stolin A, Vladimir D Lyakhovsky   +14 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Design of Computer Numerical Control System for Fiber Placement Machine Based on Siemens 840D sl

Sensors
To address the manufacturing demands of large-scale aerospace composite components, this study systematically investigates the coordinated motion characteristics of multi-axis systems in fiber placement equipment.
Kun Xia, Di Zhao, Qingqing Yuan, Jingxia Wang, Aodong Shen   +4 more
doaj   +1 more source

Interaction of Reggeized Gluons in the Baxter-Sklyanin Representation

, 2001
We investigate the Baxter equation for the Heisenberg spin model corresponding to a generalized BFKL equation describing composite states of n Reggeized gluons in the multi-color limit of QCD.
A.N. Muller, E.A. Kuraev, E.A. Kuraev, E.K. Sklyanin, G.P. Korchemsky, H. J. de Vega, H.J. de Vega, I.S. Gradshteyn, J. Bartels, J. Bartels, J. Bartels, J. Bartels, J. Kwiecinski, J. Wosiek, L. N. Lipatov, L.A. Takhtajan, L.D. Faddeev, L.N. Lipatov, L.N. Lipatov, L.N. Lipatov, L.N. Lipatov, L.N. Lipatov, L.N. Lipatov, L.N. Lipatov, M. Lavrentev, M. Praszalowicz, M.A. Braun, N.N. Lebedev, P. Gauron, P. Gauron, R. Baxter, R. Baxter, R. Baxter, R.A. Janik, V.E. Korepin, V.S. Fadin, Vl.S. Dotsenko, Ya.Ya. Balitsky, Z. Maassarani   +38 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

A Novel Flow Characteristic Regulation Method for Two-Stage Proportional Valves Based on Variable-Gain Feedback Grooves

Machines
The two-stage proportional valve is a key control component in heavy-duty equipment, where its signal-flow characteristics critically influence operational performance.
Xingyu Zhao, Huaide Geng, Long Quan, Chengdu Xu, Bo Wang, Lei Ge   +5 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source