Results 131 to 140 of about 12,654,125 (372)
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source
The different amount of composite and amalgam restoration in posterior teeth of patient
Padjadjaran Journal of Dentistry, 2014 Introduction: Dental caries is a problem that usually happens in the society. One of the treatments for dental caries is restoration. Dental restoration material which one usually used are compsite and amalgam.
Fitri Dwi Primadisya +1 more
doaj +1 more source
Composite Numbers in an Arithmetic Progression
Mathematics MagazineOne challenge (or opportunity!) that many instructors face is how varied the backgrounds, abilities, and interests of students are. In order to simultaneously instill confidence in those with weaker preparations and still challenge those able to go faster, an instructor must be prepared to give problems of different difficulty levels. Using Dirichlet's
Hùng Việt Chu +2 more
openaire +2 more sources
FEBS Letters, EarlyView.Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli +10 more
wiley +1 more source
Dynamic response and stability of a composite prop-fan model [PDF]
Results are presented for blade response and stability during wind tunnel tests of a 62.2 cm diameter model of a prop-fan, advanced turboprop, with swept graphite/epoxy composite blades.
Brooks, B. M., Smith, A. F.
core +1 more source
Investigation of Lithium Transference Number in PMMA Composite Polymer Electrolytes Using Monte Carlo (MC) Simulation and Recurrence Relation [PDF]
, 2021 Renwei Eric Koh +4 more
openalex +1 more source
Mechanisms and kinetic assays of aminoacyl‐tRNA synthetases
FEBS Letters, EarlyView.
Igor Zivkovic +2 more
wiley +1 more source
Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
FEBS Letters, EarlyView.The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen +2 more
wiley +1 more source
Research on vibration noise of the composite laminated plate structure based on the FEM-BEM
MATEC Web of Conferences, 2017 Based on the FEM-BEM hybrid method, the effects of the angle of composite layer, number of layers and the opening position of a composite material and opening form are studied in order to get these three aspects’ influence law on the vibration and ...
Xu Yang +3 more
doaj +1 more source