Results 171 to 180 of about 2,141,937 (313)
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita+1 more
wiley +1 more source
Determining the optimum number of increments in composite sampling
John E. Hathaway+4 more
openalex +2 more sources
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi+5 more
wiley +1 more source
A note on tunnel number of composite knots
Xutao Gao, Qilong Guo, Ruifeng Qiu
openalex +1 more source
Using mass cytometry, we analyzed serial blood samples from patients with relapsed epithelial ovarian cancer (EOC) treated with oleclumab–durvalumab combination immunotherapy in the NSGO‐OV‐UMB1/ENGOT‐OV30 trial. Our analysis identified potential predictive, monitoring, and response biomarkers detectable through liquid biopsy. These findings facilitate
Luka Tandaric+11 more
wiley +1 more source
Characteristics of natural convection heat transfer in composite cavity
In order to study the influence of the nature of the mining airspace on the natural convection heat transfer in the unventilated working face, we establish a numerical model of natural convection in a composite cavity containing porous media by CFD ...
Changkui Lei+5 more
doaj
In molecular cancer diagnostics, comprehensive genomic profiling (CGP) is going to replace the small NGS panels since it provides all clinically relevant somatic variants as well as genomic biomarkers with clinical value. Here, we compared two CGP assays and demonstrate that the choice for diagnostic implementation will depend on the specific ...
Guy Froyen+17 more
wiley +1 more source
THE INFLUENCE OF LAYERS NUMBER OF COMPOSITE MATERIAL ON THE STIFFNESS OF THE BEAMS [PDF]
Ianasi Aurora-Catalina
doaj +1 more source