Results 171 to 180 of about 2,141,937 (313)

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source

Determining the optimum number of increments in composite sampling

, 2008
John E. Hathaway, G. Bruce Schaalje, R.O. Gilbert, Brent A. Pulsipher, Brett D. Matzke   +4 more
openalex   +2 more sources

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

A note on tunnel number of composite knots

, 2011
Xutao Gao, Qilong Guo, Ruifeng Qiu
openalex   +1 more source

Peripheral blood leukocyte signatures as biomarkers in relapsed ovarian cancer patients receiving combined anti‐CD73/anti‐PD‐L1 immunotherapy in arm A of the NSGO‐OV‐UMB1/ENGOT‐OV30 trial

Molecular Oncology, EarlyView.
Using mass cytometry, we analyzed serial blood samples from patients with relapsed epithelial ovarian cancer (EOC) treated with oleclumab–durvalumab combination immunotherapy in the NSGO‐OV‐UMB1/ENGOT‐OV30 trial. Our analysis identified potential predictive, monitoring, and response biomarkers detectable through liquid biopsy. These findings facilitate
Luka Tandaric, Annika Auranen, Katrin Kleinmanns, René DePont Christensen, Liv Cecilie Vestrheim Thomsen, Cara Ellen Wogsland, Emmet McCormack, Johanna Mäenpää, Kristine Madsen, Karen Stampe Petersson, Mansoor Raza Mirza, Line Bjørge   +11 more
wiley   +1 more source

Characteristics of natural convection heat transfer in composite cavity

Case Studies in Thermal Engineering
In order to study the influence of the nature of the mining airspace on the natural convection heat transfer in the unventilated working face, we establish a numerical model of natural convection in a composite cavity containing porous media by CFD ...
Changkui Lei, Yaoqian Zhu, Suntong Qiu, Chengbo Wang, Ruoyu Bao, Cunbao Deng   +5 more
doaj  

On stress-strain state of a non-homogeneous composite in form of a package composed of an arbitrary finite number of elastic wedges under anti-plain deformation.

, 2014
A. V. Gasparyan, Zaven Davtyan
openalex   +1 more source

Analysis of comprehensive genomic profiling of solid tumors with a novel assay for broad analysis in clinical diagnostics

Molecular Oncology, EarlyView.
In molecular cancer diagnostics, comprehensive genomic profiling (CGP) is going to replace the small NGS panels since it provides all clinically relevant somatic variants as well as genomic biomarkers with clinical value. Here, we compared two CGP assays and demonstrate that the choice for diagnostic implementation will depend on the specific ...
Guy Froyen, Pieter‐Jan Volders, Ellen Geerdens, Severine Berden, Joni Van der Meulen, Aaron De Cock, Stefanie Vermeire, Jacques Van Huysse, Marie de Barsy, Gabriela Beniuga, Wendy W. J. de Leng, Anne M. L. Jansen, Imke Demers, Zeliha Ozgur, Hendrikus Jan Dubbink, Ernst‐Jan M. Speel, Wilfred F. J. van IJcken, Brigitte Maes   +17 more
wiley   +1 more source

THE INFLUENCE OF LAYERS NUMBER OF COMPOSITE MATERIAL ON THE STIFFNESS OF THE BEAMS [PDF]

Annals of the Oradea University: Fascicle Management and Technological Engineering, 2011
Ianasi Aurora-Catalina
doaj   +1 more source

STRESS-STRAIN RELATIONSHIPS OF COMPOSITE FOAMED CONCRETE PANEL WITH DIFFERENT NUMBER OF SHEAR CONNECTORS UNDER COMPRESSION

, 2015
Md Azree Othuman Mydin, Nangkula Utaberta, M. Y. Mohd Yusof, N. A. Amirudin   +3 more
openalex   +2 more sources