Results 171 to 180 of about 447,875 (277)

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

STRESS-STRAIN RELATIONSHIPS OF COMPOSITE FOAMED CONCRETE PANEL WITH DIFFERENT NUMBER OF SHEAR CONNECTORS UNDER COMPRESSION

, 2015
Md Azree Othuman Mydin, Nangkula Utaberta, M. Y. Mohd Yusof, N. A. Amirudin   +3 more
openalex   +2 more sources

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

Molecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh, Amelia Martinez Villarreal, Philippe Lefrançois, Jennifer Gantchev, Sriraam Sivachandran, Samy Abou Setah, Ivan V. Litvinov   +6 more
wiley   +1 more source

Investigating the Effect of Passes Number on Microstructural and Mechanical Properties of the Al2024/SiC Composite Produced by Friction Stir Processing

, 2016
Davood Ghanbari, M. Kasiri Asgharani, Kamran Amini   +2 more
openalex   +2 more sources

CircCCNB1 inhibits vasculogenic mimicry by sequestering NF90 to promote miR‐15b‐5p and miR‐7‐1‐3p processing in nasopharyngeal carcinoma

Molecular Oncology, EarlyView.
CircCCNB1 expression is down‐regulated in nasopharyngeal carcinoma (NPC); thus, less NF90 protein is bound to circCCNB1 and more binds to pri‐miRNAs, blocking their (pri‐miRNAs) binding to DGCR8 and inhibiting the processing and generation of miR‐15b‐5p/miR‐7‐1‐3p. Furthermore, decreased miR‐15b‐5p/miR‐7‐1‐3p promotes the expression of the target genes
Chunmei Fan, Fenghua Tan, Jie Wu, Zhaoyang Zeng, Wenjia Guo, He Huang, Wei Xiong   +6 more
wiley   +1 more source

THE INFLUENCE OF LAYERS NUMBER OF COMPOSITE MATERIAL ON THE STIFFNESS OF THE BEAMS [PDF]

Annals of the Oradea University: Fascicle Management and Technological Engineering, 2011
Ianasi Aurora-Catalina
doaj   +1 more source

Impact of the Type and Number of Composite Layers in Flexural Strengthening of Reinforced Concrete Voided Slabs with FRP Using Finite Element Method

, 2016
Muhammed Maleknia, Ataollah Hajati Modaraei   +1 more
openalex   +2 more sources

Composite numbers V [PDF]

Applied Mathematical Sciences, 2019
openaire   +1 more source

Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value

Molecular Oncology, EarlyView.
The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song, Zhe Wang, Guangji Zhang, Jiangxue Hou, Kaiqi Liu, Shuning Wei, Yan Li, Chunlin Zhou, Dong Lin, Min Wang, Hui Wei, Jianxiang Wang, Tao Cheng, Yingchang Mi   +13 more
wiley   +1 more source

Appendix A. A species list with life-form, total composited litter, number of traps in which litter was found, and the axis 1 score from the PCA of soluble fraction.

, 2016
Laura A. Schreeg, Michelle C. Mack, Benjamin L. Turner   +2 more
openalex   +2 more sources