Results 121 to 130 of about 2,461,830 (355)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Parametric Investigation of Fatigue-Cracked Tubular T-Joint Repair Using Composite Reinforcement

Engineering Proceedings
Circular hollow sections (CHSs) are widely used in offshore jacket structures due to their excellent compressive strength, torsional resistance, and direction-independent stiffness.
Muhammad Hazim, Saravanan Karuppanan, Mohsin Iqbal   +2 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

The influence of pyrolitic degradation on mechanical properties of carbon fibres within recycling composite materials [PDF]

, 2017
The article deals with the influence of thermal pyrolytic degradation on mechanical properties of carbon fibres used in the production of composite material. The carbon fibre has been chosen as the reinforcement of composite and the resin formed a matrix
Glogarová, Veronika, Návrat, Michal, Závada, Jaroslav   +2 more
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Study on Flexural Behavior of Large-Span Precast Ribbed Concrete Composite Slabs for Underground Subway Stations

Chengshi guidao jiaotong yanjiu
［Objective］ The large-span precast ribbed concrete composite slabs for underground subway stations have problems of thick slabs, large spans, and heavy self-weight.
YAN Hui, XU Qianwei, LU Linhai, WU Chaojun, HAN Yufeng, GONG Jie   +5 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Composite Intersection Reinforcement [PDF]

An assembly and method for manufacturing a composite reinforcement for unitizing a structure are provided. According to one embodiment, the assembly includes a base having a plurality of pins extending outwardly therefrom to define a structure about ...
Fuhrer, Jessica J., Funk, Robert S., Misciagna, David T., Tolotta, William S.   +3 more
core   +1 more source

The processing and testing of aluminium matrix composite wires, double composites and block composites [PDF]

, 2006
The Composite Processing and Testing Laboratory operated for about 15 years in USA. After that, in 2004- 2005, it moved from Boston to the Budapest University of Technology and Economics One of the main results from research and development projects is
Dobránszky, János, Kientzl, Imre, Németh, Árpád, Orbulov, Imre Norbert   +3 more
core  

Fibreglass Reinforced Composites

CeROArt, 2020
L’usage de produits en fibre de verre en restauration et les produits disponibles pouvant être utilisés pour goujons dans des sculptures en bois sont explorés. L'expérience s'est appuyée sur des tests comparatifs de capacité de charge des goujons en bois et en fibre de verre.
openaire   +1 more source