Results 91 to 100 of about 9,422,830 (251)

Translophagy—A potential link between autophagy impairment and translational errors

open access: yesFEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk   +11 more
wiley   +1 more source

Eccentric Compression Behavior of Coral Aggregate Geopolymer Concrete Columns Reinforced with Stainless-Steel Rebars

open access: yesApplied Sciences
Using coral aggregates instead of natural aggregates can save both raw material transportation costs and time in island construction projects. However, coral aggregates are characterized by high brittleness, low strength, and a high chloride content ...
Haiwen Xu, Jiasheng Jiang, Chao Yang
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

open access: yesFEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell   +2 more
wiley   +1 more source

Multiple Order Dual-Band Active Ring Filters with Composite Right/Left Handed Cells [PDF]

open access: yes, 2010
In this paper, a novel dual-band active filter topology is presented. The non-linear phase response of a composite right/left-handed cell is used to achieve the desired dual-band performance.
García Pérez, Oscar Alberto   +7 more
core   +1 more source

Mechanical characterization of lattice structures fabricated by selective laser melting via an image-based finite cell method with a damage model

open access: yesMaterials & Design
Lattice structures fabricated by the selective laser melting (SLM) additive manufacturing process hold great potential for diverse applications. However, their actual mechanical behaviors often deviate from their counterparts with the as-designed ...
Biao Zhang   +4 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

open access: yesFEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices   +3 more
wiley   +1 more source

Imperfection investigation of composite stiffened fuselage panels for Postbuckling analyses [PDF]

open access: yes, 2008
Project COCOMAT is an ongoing four year European Commission project aimed at exploiting the large reserve of strength in composite structures through more accurate prediction of collapse. As part of the research program, curved stiffened composite panels
Thomson, Rodney   +3 more
core  

Experimental study on the behaviour of composite steel-concrete beams utilising innovative blind bolts

open access: yes, 2012
This paper presents the feasibility of providing shear connection utilising innovative blind bolts. The main reason for using blind bolts is to promote structural rehabilitation of both existing structures and new construction to create a demountable ...
Uy, Brian (R9735)   +7 more
core   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

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