Results 71 to 80 of about 9,422,830 (251)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Bioinspired Double‐Broadband Switchable Microwave Absorbing Grid Structures with Inflatable Kresling Origami Actuators

Advanced Science
Tunable radar stealth structures are critical components for future military equipment because of their potential to further enhance the design space and performance.
Zhong Zhang, Hongshuai Lei, Shengyu Duan, Zeang Zhao, Mingji Chen, Changxian Wang, Daining Fang   +6 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Design and commission of an experimental test rig to apply a full-scale pressure load on composite sandwich panels representative of aircraft secondary structure

, 2009
This paper describes the design of a test rig, which is used to apply a representative pressure load to a full-scale composite sandwich secondary aircraft structure.
Crump, D.A., Savage, J., Dulieu-Barton, J.M., J M Dulieu-Barton, J Savage, D A Crump   +5 more
core   +1 more source

Ablation of C/SiC-HfC composite prepared by precursor infiltration and pyrolysis in plasma wind tunnel

Journal of Advanced Ceramics, 2020
Carbon fiber reinforced silicon carbide-hafnium carbide (C/SiC-HfC) composite was prepared by precursor infiltration and pyrolysis process. Then, ablation behavior of C/SiC-HfC was evaluated in plasma wind tunnel.
Liuyang Duan, Lei Luo, Liping Liu, Yiguang Wang   +3 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Integrity of hybrid steel-to-composite joints for marine application

, 2004
There are many instances where the use of weight-saving polymer composite material for an entire structure is either too complex, too expensive or unfeasible.
Shenoi, R.A., Blake, J.I.R., Kapadia, A., Boyd, S.W.   +3 more
core   +1 more source

Long-term oxidation of Ti3Al0.8Sn0.2C2 in air at 1200 °C

Open Ceramics
The addition of Sn into the raw materials is currently one of the most widely used methods to improve the purity and mechanical properties of Ti3AlC2. It follows in this work to investigate the oxidation behavior of the resulting Ti3Al0.8Sn0.2C2 at 1200 °
Hang Yin, Xiaodong He, Kebin Qin, Guangping Song, Yongting Zheng, Yuelei Bai   +5 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source