Results 41 to 50 of about 252,667 (267)

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Virtual testing for design and certification of (fusion) bonded longitudinal joints in a fibre composite fuselage: A proposal using FEM-based progressive damage analysis

Composites Part C: Open Access, 2022
In the design of bonded aircraft structures, the type of failure is crucial. More specifically, the failure in case of overload should be limited to the surrounding fibre composite structure.
O. Völkerink, C. Hühne
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Design and Experimental Characterization of an Actuation System for Flow Control of an Internally Blown Coanda Flap

Aerospace, 2020
The focus of the work is on the evaluation, development and integration of a robust actuator system for three-dimensional flow control of a blown Coanda flap to improve the high lift system of commercial aircraft.
Peter Wierach, Jan Petersen, Michael Sinapius   +2 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

A CAI study on transition zones of conventional and Double-Double laminates

Composites Part C: Open Access
Laminate-thickness tapering opportunities of Double-Double (DD) laminates are unique, compared to conventional laminates (denoted as Quad) in aerospace, which are typically composed of 0°, 45°, −45°, 90°plies.
Erik Kappel, Yannick Boose, Mirko Mißbach   +2 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

MXene-reduced graphene oxide sponge-based solar evaporators with integrated water-thermal management by anisotropic design

Communications Materials, 2023
The main issue limiting the performance of the solar evaporators is that water-thermal management is difficult to coordinate. Herein, we achieve integrated water-thermal management by designing hierarchical MXene-reduced graphene oxide sponges with ...
Zonglin Liu, Renjie Ding, Fuhua Xue, Xu Zhao, Zhong Chen, Haowen Zheng, Pengyang Li, Qian Yan, Liangliang Xu, Jinhua Xiong, Qingyu Peng, Xiaodong He   +11 more
doaj   +1 more source