Results 61 to 70 of about 275,064 (219)

Tissue mimicking hydrogel foam materials with mechanical and radiological properties equivalent to human lung

Scientific Reports
The motion of organs and tissues causes X-ray localization error during radiation therapy. Physical phantoms utilizing materials with tissue-equivalent mechanical and radiological properties are therefore desired to simulate organ motion for radiotherapy
Xiangpeng Li, Jihua Gou, Anand P. Santhanam, Chiranjit Maiti, Olusegun J. Ilegbusi   +4 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Linking Stochastic Resonance With Long Short‐Term Memory Neural Network for Streamflow Simulation Enhancement

Water Resources Research
The accuracy of peak streamflow simulation is often lower than that of normal streamflow simulation, posing a significant challenge. This study introduces stochastic resonance (SR) to enhance simulation accuracy, utilizing its ability to leverage noise ...
Xungui Li, Jian Sun, Qiyong Yang, Yi Tian, Xiaoli Yang   +4 more
doaj   +1 more source

Advances in Shape Memory Polymer Porous Materials: Fabrications, Microstructures, and Applications

Research
As an essential branch of smart materials, shape memory polymer materials (SMPs) have made substantial advances in fabrication strategies, microstructure design, and response methods.
Likai Hu, Fenghua Zhang, Lan Luo, Jinsong Leng   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Three-Dimensional Modeling and Analysis of Directed Energy Deposition Melt Pools Based on Physical Information Neural Networks

Applied Sciences
In Directed Energy Deposition (DED), modeling the molten pool temperature field is crucial for precise temperature control, process optimization, and quality improvement.
Xiang Han, Zhuang Qian, Xinyue Gao, Huaping Li, Zhongqing Peng, Yu Long   +5 more
doaj   +1 more source