Results 51 to 60 of about 252,667 (267)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Journal of Advanced Ceramics, 2017 The electronic structures and optical properties of the monoclinic ZrO2 (m-ZrO2) are investigated by means of first-principles local density approximation (LDA) + U approach.
Jinping Li +3 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Linguistic structure as composition and perturbation [PDF]
Proceedings of the 34th annual meeting on Association for Computational Linguistics -, 1996 This paper discusses the problem of learning language from unprocessed text and speech signals, concentrating on the problem of learning a lexicon. In particular, it argues for a representation of language in which linguistic parameters like words are built by perturbing a composition of existing parameters.
openaire +2 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Advanced Modeling and Simulation in Engineering Sciences, 2020 This paper introduces a shape optimization of wire strands subjected to tensile loads. The structural analysis relies on a recently developed reduced helical finite element model characterized by an extreme computational efficacy while accounting for ...
Francesco Maria Filotto +2 more
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Formation, Structure, and Composition of Methylaluminoxane
ChemPhysChem, 2017 AbstractThe structurally ill‐characterized methylaluminoxane (MAO) is the activator of choice in olefin polymerization catalysis. We have carried out large scale and systematic quantum chemical calculations to simulate the thermodynamics of its formation by controlled hydrolysis of trimethylaluminum (TMA), extending the studies up to 25 Al atoms, and ...
Mikko Linnolahti, Scott Collins
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
The engineering method for unifying ground floor slab settlements
Engineering Structures and Technologies, 2020 For industrial buildings and logistics centres truck lifts are usually used. Therefore, there are special requirements for flatness tolerance of ground floor. The ground floor settlements differences in selected distances are limited. The article reviews
Kęstutis Urbonas +2 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source