Results 121 to 130 of about 2,190,509 (268)

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

open access: yesFEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani   +3 more
wiley   +1 more source

Effects of honey compounded with Colla Corii Asini powder on antioxidant capacity and intestinal flora of mouse model

open access: yesShipin yu jixie
ObjectiveTo explore the regulatory effects and changing characteristics of the compound of Colla Corii Asini powder and honey on the antioxidant activity and intestinal flora of mice.MethodsSeventy male BALB/c mice of SPF (Specific Pathogen Free, SPF ...
LI Cong   +6 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Single whispering-gallery mode lasing from free-standing microdisk with InGaN/GaN quantum wells

open access: yes, 2014
Room‐temperature single whispering‐gallery mode (WGM) lasing has been observed in optically‐pumped free‐standing InGaN/GaN quantum well microdisks at room temperature.
Zhang, X, Choi, HW
core  

Japanese Compounds with the Lexeme 'Mouth': Word Formation and Meanings

open access: yesLingua Cultura
In Japanese, the lexeme ‘mouth’ can be written using kanji 口 read as ‘kuchi’. It is a commonly used character that includes idiomatic expressions and compound words.
Made Henra Dwikarmawan Sudipa   +2 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

III-V Compound SemiconductorIndustry and Technology Development in Taiwan

open access: yes, 2012
[[abstract]]This paper reviews the current status of the compound semiconductor industry and technology development in Taiwan[[fileno]]2030182030001[[department ...
Yung S. Liu
core  

BrisClimate/Compound-temps-covid-mortality-paper: v1

open access: yes
Code associated with Lo et al., 2024, Compound mortality impacts from extreme temperatures and the COVID-19 pandemic.
Eunice Lo
core   +1 more source

Compound-Specific Chlorine Isotope Analysis of the Herbicides Atrazine, Acetochlor, and Metolachlor

open access: yes, 2019
A gas chromatography–single quadrupole mass spectrometry method was developed and validated for compound-specific chlorine isotope analysis (Cl-CSIA) of three chlorinated herbicides, atrazine, acetochlor, and metolachlor, which are widespread ...
Violaine Ponsin (6325994)   +4 more
core   +1 more source

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