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Schistosomes: challenges in compound screening
Expert Opinion on Drug Discovery, 2007Major progress in studying the biology of schistosomes had been achieved since the late 1960s with the successful laboratory cultivation of the parasite's life cycle stages in the vertebrate (in vivo animal models) and snail hosts. This was followed by establishment of in vitro culture techniques for cultivation of the different life cycle stages to ...
Quentin Bickle +2 more
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Ultraviolet radiation screening compounds
Biological Reviews, 1999ABSTRACTAmongst the diversity of methods used by organisms to reduce damage caused by ultraviolet (UV) radiation, the synthesis of UV‐screening compounds is almost ubiquitous. UV‐screening compounds provide a passive method for the reduction of UV‐induced damage and they are widely distributed across the microbial, plant and animal kingdoms. They share
C S, Cockell, J, Knowland
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The Future of Virtual Compound Screening
Chemical Biology & Drug Design, 2012We provide a future perspective of the virtual screening field. A number of challenges will be highlighted that virtual screening will likely face when compound data will further grow at or beyond current rates and when much more target information will become available.
Kathrin, Heikamp, Jürgen, Bajorath
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The evolution of microarrayed compound screening
Drug Discovery Today, 2004This review describes recent developments in the evolutionary process of microarrayed compound screening (microARCS to become a robust and efficient ultra-high-throughput screening technology. Improvements in compound spotting (including new quality-control methods), gel casting and imaging, together with software capable of automatic analysis and ...
Michael, Hoever, Peter, Zbinden
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A network view of disease and compound screening
Nature Reviews Drug Discovery, 2009The large-scale generation and integration of genomic, proteomic, signalling and metabolomic data are increasingly allowing the construction of complex networks that provide a new framework for understanding the molecular basis of physiological or pathophysiological states.
Eric E, Schadt +2 more
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Screening Assay for Promigratory/Antimigratory Compounds
Analytical Biochemistry, 2000Large-scale screening strategies aimed at finding anticancer drugs traditionally focus on identifying cytotoxic compounds that attack actively dividing cells. Because progression to malignancy involves acquisition of an aggressively invasive phenotype in addition to hyperproliferation, simple and effective screening strategies for finding compounds ...
W L, Rust, J L, Huff, G E, Plopper
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Substituted tetrazoles as multipurpose screening compounds
Molecular Diversity, 2016Tetrazoles are small functional heterocycles that are suited to serve simultaneously as aromatic platform for diversity and as functional interaction motif. Furthermore, the tetrazole ring and its deprotonated tetrazolate counterpart are metal ion complexing ligands that possess a rich variety of binding and bridging modes.
Nicole Rüger +5 more
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