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Strategic Pooling of Compounds for High-Throughput Screening
Journal of Chemical Information and Computer Sciences, 1999Bringing new medicines to the market depends on the rapid discovery of new and effective drugs, often initiated through the biological testing of many thousands of compounds in high-throughput screening (HTS). Mixing compounds together into pools for screening is one way to accelerate this process and reduce costs.
Mike Hann +5 more
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Kernels for Chemical Compounds in Biological Screening
2007Kernel methods are a class of algorithms for pattern analysis with a number of convenient features. This paper proposes extension of the kernel method for biological screening data including chemical compounds. Our investigation of extending kernel aims to combine properties of graphical structure and molecule descriptors.
Karol Kozak +2 more
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A Method for Screening of Volatile Antimicrobial Compounds
Bulletin of Environmental Contamination and Toxicology, 2011Presently available methods for determining antimicrobial activity include broth dilution and disc diffusion. However, these methods can not be employed for study of vapor phase antimicrobial activity. The present study describes a new method and a new apparatus for determination of vapor phase antimicrobial activity of volatile substances against ...
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ELECTROSTATIC SCREENING IN FULLERENE COMPOUNDS
Modern Physics Letters B, 1994We study the Coulomb interactions in fullerene compounds within a continuum formalism. The model gives rise to a renormalizable field theory, which has many similarities to standard quantum electrodynamics. The effective electric charge at low energies is reduced by screening processes.
J. GONZÁLEZ +2 more
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Screening for Anti-proteolytic Compounds
2009Dietary protein entering the rumen is broken down in an apparently uncontrolled way, resulting in ammonia formation and subsequent loss of N in the urine. The low efficiency of nitrogen retention represents a major economic loss, causes metabolic stress in the animal, and places a burden on the environment, by way of nitrogen-rich wastes. If a means of
Ellen M. Hoffmann +4 more
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[Screening of antiangiogenic compound].
Gan to kagaku ryoho. Cancer & chemotherapy, 2004Cancer cells promote angiogenesis early in tumorigenesis because cancer cells require oxygen and nutrients for their survival they need to be supported by blood vessels. The angiogenic switch is driven by several proangiogenic factors, vascular endothelial growth factor (VEGF), interleukin-8 (IL-8), basic fibroblast growth factor (bFGF) and others ...
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Screening Microorganisms for Bioactive Compounds
2016Novel bioactive compounds are in high demand due to the development of microbial antibiotic resistance, increase in age-related diseases, and requirements for optimized manufacturing processes. The bioactive compounds can act as specific antitumor, anti-inflammatory, and antifungal compounds as well as pharmaceuticals against metabolic diseases ...
Sonia Giubergia +6 more
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Social determinants of health and US cancer screening interventions: A systematic review
Ca-A Cancer Journal for Clinicians, 2023Ariella R Korn +2 more
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