Results 121 to 130 of about 1,724,580 (253)

Early‐Phase Research in Pediatric Neuro‐Oncology

Pediatric Blood &Cancer, EarlyView.
Jonathan Cunningham
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Synthesis, Characterization, Antioxidant Evaluation, Cytotoxicity Studies, and Molecular Docking of Novel Sulfonamide Derivatives. [PDF]

J Biochem Mol Toxicol
Bouraoui O, Şekerci G, Mesbah K, Ezugwu JA, Benkiniouar R, Tekin S, Küçükbay F, Boulebd H, Küçükbay H.   +8 more
europepmc   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Enzyme Inhibition by Bioactive Compounds from Olive (<i>Olea europaea</i> L.) and Pomegranate (<i>Punica granatum</i> L.): Systematic Review of In Vitro Studies. [PDF]

Molecules
Vučina R, Drmač D, Rezić V, Čulum D, Kondža M.   +4 more
europepmc   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Linking Degradation Pathways, Additive Transformation, and Contaminant Profiles in Post-Consumer HDPE: Implications for Recycling Quality. [PDF]

Polymers (Basel)
Kucbel M, Raclavská H, Růžičková J, Šafář M, Švédová B, Slamová K, Kantor P, Braun P.   +7 more
europepmc   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Antiparasitic Potential of Bioactive Compounds From <i>Punica granatum</i>: Preventive and Therapeutic Effects. [PDF]

J Parasitol Res
Vargas-Villanueva JR, Gutiérrez-Gutiérrez F, Ochoa-Maganda VY, Nery-Flores SD, Palomo-Ligas L.   +4 more
europepmc   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source