Results 101 to 110 of about 551,632 (240)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Métaphores et dessins comme voies d’accès aux représentations des apprenants sur la compréhension orale [PDF]

Synergies Mexique, 2016
Dans cet article nous présentons une partie des résultats d’une recherche faite auprès d’étudiants et de professeurs de français et d’anglais du Centre d’enseignement de langues étrangères (CELE) de l’Université Nationale Autonome du Mexique (UNAM) sur ...
Silvia López del Hierro, María Teresa Mallén Estebaranz   +1 more
doaj  

Sémantique inférentielle et compréhension des verbatim clients

SHS Web of Conferences, 2012
Partant des deux postulats suivants : 1. la structuration sémantique des textes peut être décrite au moyen de l’inférence. 2. il existe au moins trois niveaux d’inférence : lexicale, discursive et pragmatique, nous étudions trois types d'inférences ...
Massoussi Taoufik, Doucy Geoffrey
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Pourquoi enseigner les musiques de langue-culture ? [PDF]

Synergies Espagne, 2008
L’ensemble complexe des phénomènes sonores et musicaux de l’expression langagière humaine est culturel. La perception de la musique d’une langue détermine le désir d’apprendre et la compréhension de la langue-culture d’autrui.
Sophie Aubin
doaj  

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Conversations multimodales: l'enseignement-apprentissage des langues à l'heure des écrans partagés

, 2006
The use of an audiographic environment such as Lyceum allows multimodal communication between language learners. In particular, they can hold conversations in real time both orally and in writing.
Lamy, Marie-Noëlle
core  

Dynamique d'un nuage de bulles homogène confiné [PDF]

, 2013
De nombreuses applications industrielles mettent en jeu des écoulements à bulles dans des échangeurs de masse et de chaleur ou des réacteurs. Les mouvements des bulles génèrent de l'agitation dans le liquide qui, en retour, influence la distribution ...
Billet, Anne-Marie, Bouche, Emmanuella, Risso, Frédéric, Roig, Véronique   +3 more
core  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source