Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
User evaluation of AI- and human-generated responses in digital health communication: a paired survey study. [PDF]
BMC Health Serv ResSchulz C +9 more
europepmc +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
How do the measurement properties of the broad-band scales for attention-deficit/hyperactivity disorder in children perform based on the COSMIN guidelines? [PDF]
BMC PediatrChen Y +5 more
europepmc +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Comprehensibility of Fact Sheets Addressing Benefits and Risks of Preventive Interventions: A Cross-Sectional Evaluation Study. [PDF]
MDM Policy PractHut B +5 more
europepmc +1 more source
[Comprehensiveness in practice (or, on the practice of comprehensiveness)].
Cadernos de saude publica, 2005 This article reflects on the manifestations or signs of comprehensiveness in health practice, seeking to facilitate recognition of experiences that are advancing in this direction and allowing them to be analyzed subsequently. The article is also intended to spawn increasing involvement by actors in practices based on comprehensiveness.
openaire +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Improving patient communication and understanding of medical reports through text simplification with ChatGPT: a comparative study. [PDF]
Oral Maxillofac SurgStephan D +4 more
europepmc +1 more source