Results 91 to 100 of about 2,741,781 (306)

[Implementation of the Comprehensive Health Care Policy in Cundinamarca, Colombia 2021]. [PDF]

Rev Salud Publica (Bogota), 2023
Escobar-Díaz FA.
europepmc   +1 more source

GEOGRAPHIC PROFILE OF HEALTHCARE NEEDS AND NON-ACUTE HEALTHCARE SUPPLY IN IRELAND. ESRI RESEARCH SERIES NUMBER 90 JULY 2019 [PDF]

, 2019
This report provides evidence on the supply of and need for non-acute primary, community and long-term care across geographic areas in Ireland in 2014.
Barron, Steve, Eighan, James, Lyons, Seán, Morgenroth, Edgar, Smith, Samantha, Walsh, Brendan, Wren, Maev-Ann   +6 more
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Response to Chagas disease in Brazil: strategic milestones for achieving comprehensive health care. [PDF]

Rev Soc Bras Med Trop, 2022
Ramos AN, Souza EA, Guimarães MCS, Vermeij D, Cruz MM, Luquetti AO, Diotaiuti L, Palmeira SL, Lima MM, Costa VMD, Andrade LAB, Correia D, Sousa AS.   +12 more
europepmc   +1 more source

Rationale, design and conduct of a comprehensive evaluation of a primary care based intervention to improve the quality of life of osteoarthritis patients. The PraxArt-project: a cluster randomized controlled trial [ISRCTN87252339] ; study protocol [PDF]

, 2005
Background: Osteoarthritis (OA) has a high prevalence in primary care. Conservative, guideline orientated approaches aiming at improving pain treatment and increasing physical activity, have been proven to be effective in several contexts outside the ...
Thomas Rosemann, Thorsten Körner, Michel Wensing, Jochen Gensichen, Christiane Muth, Stefanie Joos, Joachim Szecsenyi, AD Woolf, DT Felson, C Neville, LM Buckley, GH de Bock, DT Felson, B Mazieres, A Warsi, W Zhang, DH Solomon, R Grol, R Grol, JM Grimshaw, M Wensing, J Rene, L R., M Campbell, MK Campbell, T Rosemann, F Guillemin, U Aberdeen, R Altman, R Grol, R Grol, B Lowe   +31 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Redesigning an Electronic Health Record in Argentina to Improve Comprehensive Health Care and Clinical Research. [PDF]

Stud Health Technol Inform, 2022
Giraldo L, Fink V, Cahn F, Caceres B, Sued O, Duda S, Cesar C.   +6 more
europepmc   +1 more source

Research Advances: January 2014 [PDF]

, 2014
The VA has a comprehensive research agenda to help the newest generation of Veterans -- those returning from operations Enduring Freedom, Iraqi Freedom, and New Dawn.

core  

Wandel im Gesundheitswesen: Analyse der Auswirkungen auf Ärzte und Patienten am Beispiel der Ukraine [PDF]

, 2020
Background The health care sector is experiencing a drastic transition all over the world. This has an impact not only on the way hospitals, clinics, special-care homes etc.
Bogodistov, Yevgen, Krupskyi, Oleksandr P., Moormann, Jürgen, Reck, Fynn Malte   +3 more
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source