Results 81 to 90 of about 16,850,204 (302)

Response to Chagas disease in Brazil: strategic milestones for achieving comprehensive health care. [PDF]

Rev Soc Bras Med Trop, 2022
Ramos AN, Souza EA, Guimarães MCS, Vermeij D, Cruz MM, Luquetti AO, Diotaiuti L, Palmeira SL, Lima MM, Costa VMD, Andrade LAB, Correia D, Sousa AS.   +12 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

[Implementation of the Comprehensive Health Care Policy in Cundinamarca, Colombia 2021]. [PDF]

Rev Salud Publica (Bogota), 2023
Escobar-Díaz FA.
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Prognostic Biomarkers in COVID-19: Prediction of Critical Outcomes and Mortality

COVID
COVID-19, caused by the SARS-CoV-2 coronavirus, emerged as a global pandemic in 2020, with profound impacts on public health and a substantial burden on intensive care units (ICUs).
Joise Wottrich, Lucas Machado Sulzbacher, Maicon Machado Sulzbacher, Vítor Antunes de Oliveira, Pauline Brendler Goettems Fiorin, Mirna Stela Ludwig, Thiago Gomes Heck, Matias Nunes Frizzo   +7 more
doaj   +1 more source

Redesigning an Electronic Health Record in Argentina to Improve Comprehensive Health Care and Clinical Research. [PDF]

Stud Health Technol Inform, 2022
Giraldo L, Fink V, Cahn F, Caceres B, Sued O, Duda S, Cesar C.   +6 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

COVID-19 and the legislative response in India: The need for a comprehensive health care law. [PDF]

J Public Aff, 2021
Gowd KK, Veerababu D, Reddy VR.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

O papel do Núcleo de Apoio à Saúde da Família na coordenação assistencial da Atenção Básica: limites e possibilidades

Saúde em Debate
RESUMO O objetivo deste estudo foi o de analisar como o Núcleo de Apoio à Saúde da Família tem colaborado com as Equipes de Saúde da Família na sua função de coordenação assistencial.
Fabiana de Oliveira Silva Sousa, Paulette Cavalcanti de Albuquerque, Cynthia Maria Barbosa do Nascimento, Luciana Camelo de Albuquerque, Aline Cavalcante de Lira   +4 more
doaj   +1 more source