Results 61 to 70 of about 16,850,204 (302)

The Evolution, Current Landscape, and Future Prospects of Oncolytic Virotherapy in Melanoma: Talimogene Laherparepvec and Beyond

Cells
Oncolytic viruses represent an emerging class of therapeutic agents that have the potential to transform the care of patients with melanoma. In this narrative review, we describe the evolution of oncolytic virus approaches.
John Smestad, John Rieth, Douglas Laux, Mohammed Milhem   +3 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Matrix Support: interface between Specialty Dental Centers and primary oral health care in Brazil

BMC Health Services Research
Background Matrix Support (MS) is a strategy that can be used to improve integration between Primary Health Care (PHC) and other levels of care. Objective The aim of this study was to investigate the association between MS carried out in Brazilian Dental
Thaislaine Gonçalves Martins Santos, Livia Fernandes Probst, Rafaela da Silveira Pinto, Edilson José Zafalon, Alessandro Diogo De-Carli   +4 more
doaj   +1 more source

A integralidade na assistência à saúde da criança na visão dos cuidadores

Saúde em Debate
O artigo identifica o atributo integralidade e elementos do cuidado integral para resolução de problemas de saúde das crianças na percepção de seus cuidadores.
Rosane Meire Munhak da Silva, Cláudia Silveira Viera, Beatriz Rosana Gonçalves de Oliveira Toso, Eliane Tatsch Neves, Reinaldo Antônio da Silva-Sobrinho   +4 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

A Brand-New Drainage Fluid Predictor, ICAM-1 for Implant Loss After the Immediate Reconstruction of Breast

Breast Cancer: Targets and Therapy
Chenyang He,1,* Yezhen Jiang,2,* Renyang Zhao,1,* Jia Liu,1 Haiying Yang,1 Rongqiang Zhang,3 Yang Zhao1 1The Comprehensive Breast Care Center, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi Province ...
He C, Jiang Y, Zhao R, Liu J, Yang H, Zhang R, Zhao Y   +6 more
doaj  

The users' perception in relation to health practices: a literary analysis

Online Brazilian Journal of Nursing, 2009
<p><span style="font-size: 10pt; color: black; font-family: 'Arial','sans-serif'">The health care practices have become object of study when it comes to knowing profoundly the patients’ perception about daily health care services.
Gicelle Galvan Machineski, Maria Alice Dias da Silva Lima, Ana Lucia de Lourenzi Bonilha, Jacó Fernando Schneider   +3 more
doaj  

Comprehensive health care of children.

American Journal of Public Health and the Nations Health, 1968
COMPREHENSIVE health care of children is a coordinated system of delivery of health and related care which provides children and their families with optimal health care on a continuing basis throughout the entire period of growth and development. It goes beyond "care" in the traditional sense of purely medical care.
H M, Wallace, S W, Dooley, R L, Thiele, C, Fraser, V, Eisner   +4 more
openaire   +3 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source