Results 51 to 60 of about 1,083,136 (261)

The Evolution, Current Landscape, and Future Prospects of Oncolytic Virotherapy in Melanoma: Talimogene Laherparepvec and Beyond

Cells
Oncolytic viruses represent an emerging class of therapeutic agents that have the potential to transform the care of patients with melanoma. In this narrative review, we describe the evolution of oncolytic virus approaches.
John Smestad, John Rieth, Douglas Laux, Mohammed Milhem   +3 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

A integralidade na assistência à saúde da criança na visão dos cuidadores

Saúde em Debate
O artigo identifica o atributo integralidade e elementos do cuidado integral para resolução de problemas de saúde das crianças na percepção de seus cuidadores.
Rosane Meire Munhak da Silva, Cláudia Silveira Viera, Beatriz Rosana Gonçalves de Oliveira Toso, Eliane Tatsch Neves, Reinaldo Antônio da Silva-Sobrinho   +4 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Matrix Support: interface between Specialty Dental Centers and primary oral health care in Brazil

BMC Health Services Research
Background Matrix Support (MS) is a strategy that can be used to improve integration between Primary Health Care (PHC) and other levels of care. Objective The aim of this study was to investigate the association between MS carried out in Brazilian Dental
Thaislaine Gonçalves Martins Santos, Livia Fernandes Probst, Rafaela da Silveira Pinto, Edilson José Zafalon, Alessandro Diogo De-Carli   +4 more
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

A Brand-New Drainage Fluid Predictor, ICAM-1 for Implant Loss After the Immediate Reconstruction of Breast

Breast Cancer: Targets and Therapy
Chenyang He,1,* Yezhen Jiang,2,* Renyang Zhao,1,* Jia Liu,1 Haiying Yang,1 Rongqiang Zhang,3 Yang Zhao1 1The Comprehensive Breast Care Center, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi Province ...
He C, Jiang Y, Zhao R, Liu J, Yang H, Zhang R, Zhao Y   +6 more
doaj  

The users' perception in relation to health practices: a literary analysis

Online Brazilian Journal of Nursing, 2009
<p><span style="font-size: 10pt; color: black; font-family: 'Arial','sans-serif'">The health care practices have become object of study when it comes to knowing profoundly the patients’ perception about daily health care services.
Gicelle Galvan Machineski, Maria Alice Dias da Silva Lima, Ana Lucia de Lourenzi Bonilha, Jacó Fernando Schneider   +3 more
doaj  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Metodologia feminista e direitos reprodutivos no Centro de Saúde Santa Rosa, Niterói (RJ)

Saúde em Debate
O presente trabalho tem por objetivo examinar práticas feministas e femininas, em especial, aquelas presentes em uma pedagogia voltada para o processo de empoderamento político das mulheres, a Linha da Vida, largamente utilizada nas lutas dos anos de ...
Elaine França da Silva
doaj   +1 more source