Results 71 to 80 of about 1,083,136 (261)

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

O papel do Núcleo de Apoio à Saúde da Família na coordenação assistencial da Atenção Básica: limites e possibilidades

Saúde em Debate
RESUMO O objetivo deste estudo foi o de analisar como o Núcleo de Apoio à Saúde da Família tem colaborado com as Equipes de Saúde da Família na sua função de coordenação assistencial.
Fabiana de Oliveira Silva Sousa, Paulette Cavalcanti de Albuquerque, Cynthia Maria Barbosa do Nascimento, Luciana Camelo de Albuquerque, Aline Cavalcante de Lira   +4 more
doaj   +1 more source

COVID-19 and the legislative response in India: The need for a comprehensive health care law. [PDF]

J Public Aff, 2021
Gowd KK, Veerababu D, Reddy VR.
europepmc   +1 more source

Comprehensive health care of children.

American Journal of Public Health and the Nations Health, 1968
COMPREHENSIVE health care of children is a coordinated system of delivery of health and related care which provides children and their families with optimal health care on a continuing basis throughout the entire period of growth and development. It goes beyond "care" in the traditional sense of purely medical care.
H M, Wallace, S W, Dooley, R L, Thiele, C, Fraser, V, Eisner   +4 more
openaire   +3 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Integralidade na perspectiva de enfermeiros da Estratégia Saúde da Família

Revista Bioética
Resumo Este estudo objetivou conhecer a percepção de enfermeiros sobre a integralidade do ser humano na prática do cuidado de enfermagem no contexto da Estratégia Saúde da Família.
Fabiana da Penha Colimoide, Maria Dyrce Dias Meira, Gina Andrade Abdala, Sarah Lidiane Santos da Silva Oliveira   +3 more
doaj   +1 more source

Modelling trends of CD4 counts for patients on antiretroviral therapy (ART): a comprehensive health care clinic in Nairobi, Kenya. [PDF]

BMC Infect Dis, 2022
Mugo CW, Shkedy Z, Mwalili S, Awoke T, Braekers R, Wandede D, Mwachari C.   +6 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Macrocytic anemia, kidney dysfunction, and mortality in general population: Japan specific health checkup study

Scientific Reports
Anemia and chronic kidney disease (CKD), which worsen bidirectionally, are associated with mortality in older adults. This study aimed to examine the association between CKD and the type of anemia and its impact on mortality in the general population ...
Yoichiro Otaki, Tetsu Watanabe, Tsuneo Konta, Masafumi Watanabe, Koichi Asahi, Kunihiro Yamagata, Shouichi Fujimoto, Kazuhiko Tsuruya, Ichiei Narita, Masato Kasahara, Yugo Shibagaki, Kunitoshi Iseki, Toshiki Moriyama, Masahide Kondo, Tsuyoshi Watanabe   +14 more
doaj   +1 more source