Results 221 to 230 of about 23,921,062 (292)

Recent Advances in Top‐Down Proteomics for Single‐Cell Research

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Individual cells have distinctive molecular characteristics, including biologically relevant proteoforms. Although single‐cell (SC) molecular omics offer unprecedented insights into cellular heterogeneity and function, the characterization of proteoforms in SCs remains an uncharted territory.
Jake A. Melby, Pei Su, Fabio P. Gomes
wiley   +1 more source

Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág, Krisztián Márk Karvaly, Alexandra Molnár, Mirjam Balbisi, Júlia Németh, Lilla Turiák   +5 more
wiley   +1 more source

Proteoforms in Disease: Biomedical Applications of Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The proteome is a dynamic landscape of proteoforms arising from genetic mutations, alternative splicing, and post‐translational modifications (PTMs), which collectively drive biological function and disease phenotypes. Mass spectrometry (MS)‐based proteomics has emerged as an essential technique for elucidating this molecular complexity ...
Holden T. Rogers, Zachery R. Gregorich, Megan S. Gant, Zhan Gao, Julia Chamot‐Rooke, Ying Ge   +5 more
wiley   +1 more source

Surface fitting for calculating the second dimension retention index in comprehensive two-dimensional gas chromatography mass spectrometry. [PDF]

J Chromatogr A, 2018
Prodhan MAI, Yin X, Kim S, McClain C, Zhang X.   +4 more
europepmc   +1 more source

Mass Spectrometry in Authentication and Forensic Approaches for Determining the Origin of Hazardous Chemicals

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Identification of a chemical agent yields insights into its physicochemical properties. By examining the intrinsic characteristics and environment of a compound, information about its history can be gathered. The main objective of authentication/forensic approaches to chemicals is to trace the history of the compound's origin, regardless of ...
Carla Orlandi, Grégoire Delaporte, Christine Albaret, Emmanuel Joubert, Anne Bossée, Emilien L. Jamin, Laurent Debrauwer   +6 more
wiley   +1 more source

Analysis of sesquiterpene hydrocarbons in grape berry exocarp (Vitis vinifera L.) using in vivo-labeling and comprehensive two-dimensional gas chromatography-mass spectrometry (GC×GC-MS). [PDF]

Beilstein J Org Chem, 2019
Könen PP, Wüst M.
europepmc   +1 more source

Keeping It Native: Non‐Denaturing Approaches to Top‐Down Protein Mass Spectrometry

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Top‐down proteomics and top‐down mass spectrometry approaches provide direct characterization of proteoforms; the specific molecular forms of proteins, including post‐translational modifications, truncations, alternative splicing, and sequence variants.
Michael Xiao, Edvaldo Vasconcelos Soares Maciel, Frederik Lermyte, Owen S. Skinner   +3 more
wiley   +1 more source

Carbon sequestration strategies for climate resilience: Sorghum‐based innovations for sustainable agriculture in dryland regions

PLANTS, PEOPLE, PLANET, EarlyView.
Climate change is intensifying heat, drought, and food insecurity, threatening dryland farming and carbon management worldwide. We reviewed research on sorghum, a drought‐adapted C4 crop, covering physiology, roots, biomass allocation, soil carbon, bioenergy, breeding, phenotyping, management, and policy.
Monir Idres Yahya Ahmed, Ahmed Khaled Hassan Mohammedali, Nasrein Mohamed Kamal, Takashi Okamoto, Takayoshi Ishii   +4 more
wiley   +1 more source

Novel tetronamides derived from mucobromic acid: synthesis, structural elucidation, DFT calculations and phytotoxic activity

Pest Management Science, EarlyView.
The acyclic mucobromic acid, activated by (1S)‐(+)‐10‐camphorsulfonic acid, afforded the chiral compound 1b, precursor for aza‐Michael addition/elimination on the butenolide yielding tetronamides 2b‐7b. Their relative SRSR configuration was confirmed by the spectrometric methods, DFT calculation and statistical methods.
Kamylla CF Faria, Vitor C Baia, Elson S Alvarenga   +2 more
wiley   +1 more source

In planta fluxapyroxad gradients from seed treatment differentially select fungicide‐sensitive and reduced‐sensitive genotypes of Pyrenophora teres f. maculata

Pest Management Science, EarlyView.
Spatial concentration gradients of seed‐applied fluxapyroxad within barley create heterogeneous exposure environments, driving differential suppression of succinate dehydrogenase inhibitor‐sensitive Pyrenophora teres f. maculata isolates and enrichment of reduced‐sensitive genotypes, thereby shaping within‐host fungicide resistance selection dynamics ...
Arundhati Singh, Elizabeth Czislowski, Mark Gibberd, Kefei Chen, Francisco J Lopez‐Ruiz, M Jordi Muria‐Gonzalez   +5 more
wiley   +1 more source