Results 91 to 100 of about 5,883,031 (297)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Tangent curve utilization for description of mechanical behaviour of pressed mixture

open access: yesResearch in Agricultural Engineering, 2011
This article is focused on the utilization of tangent curve for description of mechanical behaviour of pressed mixture under compression loading. The aim of this experiment was to determine the general equation describing deformation characteristics of ...
D. Herák   +3 more
doaj   +1 more source

Static 3D Triangle Mesh Compression Overview [PDF]

open access: yes, 2008
3D triangle meshes are extremely used to model discrete surfaces, and almost always represented with two tables: one for geometry and another for connectivity.
Marcos Aviles   +3 more
core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

open access: yesMolecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu   +3 more
wiley   +1 more source

Attacking the Knudsen-Preneel Compression Functions [PDF]

open access: yes, 2010
Knudsen and Preneel (Asiacrypt'96 and Crypto'97) introduced a hash function design in which a linear error-correcting code is used to build a wide-pipe compression function from underlying blockciphers operating in Davies-Meyer mode. In this paper, we (re)analyse the preimage resistance of the Knudsen-Preneel compression functions in the setting of ...
Hong, Seokhie   +4 more
openaire   +4 more sources

Folder 3: Model engine data sheets and operating instructions, C - D, 1946, 1950, 1960

open access: yes, 1946
Instructions for fueling and starting a Compression Ignition Engines model ...
Compression Ignition Engines
core  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

open access: yesMolecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas   +16 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

The effect of simultaneous application of contrast temperature therapy and intermittent compression on recovery following exercise induced muscle damage [PDF]

open access: yes, 2011
Objective: To determine the effects of the simultaneous application of contrast temperature therapy with intermittent compression as a recovery strategy for the quadriceps muscle following exercise induced muscle damage in moderately active adult ...
Holroyd, Wayne
core   +1 more source

In-Band Disparity Compensation for Multiview Image Compression and View Synthesis [PDF]

open access: yes, 2010
This paper presents a novel framework to achieve scalable multiview image compression and view synthesis. The open-loop wavelet-lifting scheme for geometric filtering has been exploited to achieve signal-to-noise ratio scalability and view-type ...
Anantrasirichai, N   +3 more
core   +1 more source

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