Results 71 to 80 of about 484,851 (292)

Compressing and Indexing Aligned Readsets

, 2018
In this paper we show how to use one or more assembled or partially assembled genome as the basis for a compressed full-text index of its readset. Specifically, we build a labelled tree by taking the assembled genome as a trunk and grafting onto it the reads that align to it, at the starting positions of their alignments.
Gagie T., Gourdel G., Manzini G.
openaire   +6 more sources

Biallelic Inactivation of NSD1 Associated With Carcinogenesis in Sotos Syndrome

Pediatric Blood &Cancer, EarlyView.
Nicholas A. Borja, Anuja Sule, Katie Ann McMullen, Aditi Dhir, Matthew D. Hall, Heather J. McCrea, Sakir Humayun Gultekin, Mustafa Tekin, Bradley Gampel   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A simple online competitive adaptation of Lempel-Ziv compression with efficient random access support [PDF]

, 2013
We present a simple adaptation of the Lempel Ziv 78' (LZ78) compression scheme ({\em IEEE Transactions on Information Theory, 1978}) that supports efficient random access to the input string.
Dutta, Akashnil, Levi, Reut, Ron, Dana, Rubinfeld, Ronitt   +3 more
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Shock waves in tidally compressed stars by massive black holes

, 2008
We interest in the case of a main-sequence star deeply penetrating within the tidal radius of a massive black hole. We focus on the compression phase leading to a so-called pancake configuration of the star at the instant of maximal compression.
Ayal, Bicknell, Carter, Carter, Carter, Carter, Diener, Evans, Ferrarese, Frank, Fulbright, Hills, Ivanov, J.-P. Luminet, Karas, Khokhlov, Kim, Kobayashi, Kochanek, Komossa, Laguna, Lee, Luminet, Luminet, Luminet, Luminet, M. Brassart, Magorrian, Marck, Martí, Nolthenius, Nolthenius, Novikov, Pichon, Rees, Regev, Renzini   +36 more
core   +2 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Heterogeneidade da compactação de um latossolo vermelho-amarelo sob pomar de laranja Compaction heterogeneity of a haplustox under an orange orchard

Revista Brasileira de Ciência do Solo, 2004
A heterogeneidade na compactação do solo, provocada por diferentes intensidades de tráfego, pode limitar a produção em áreas citrícolas. O objetivo deste trabalho foi quantificar o índice de compressão (IC) e a pressão de preconsolidação (sigmap) nas ...
C. L. R. Lima, A. P. Silva, S. Imhoff, H. V. Lima, T. P. Leão   +4 more
doaj   +1 more source

First order Fermi acceleration driven by magnetic reconnection

, 2012
A box model is used to study first order Fermi acceleration driven by magnetic reconnection. It is shown, at least in this simple model, that the spectral index of the accelerated particles is related to the total compression in the same way as in ...
Axford, Bell, Blandford, de Gouveia dal Pino, Drury, Giannios, Krymskii, L. O’C. Drury, Lazarian, Speiser   +9 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source