Results 71 to 80 of about 871,514 (303)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Modelo elástico ortotrópico aplicado a la madera

Maderas: Ciencia y Tecnología, 2014
La madera, entre los materiales de construcción, presenta un comportamiento ortotrópico, esto debido a su estructura interna con tres ejes elásticos de simetría: longitudinal, tangencial y radial.
Nilson Tadeu Mascia
doaj  

Tailoring the mechanical properties of Ti6Al4V diamond metal lattice structures through a novel node-compensation technique targeting cortical bone

Materials Research Express
This study introduces a novel node compensation (NC) technique for Ti6Al4V-based diamond metal lattice structures (MLSs). This approach reduces the stress concentration at strut junctions while enhancing the energy absorption capacity of the MLS.
Shivakumar N, T Ramesh, Muthukumaran S
doaj   +1 more source

Compression Stress Effect on Dislocations Movement and Crack propagation in Cubic Crystal [PDF]

, 2011
Fracture material is seriously problem in daily life, and it has connection with mechanical properties itself. The mechanical properties is belief depend on dislocation movement and crack propagation in the crystal.
Aprilia, Ely, Suprijadi, Yusfi, Meiqorry
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Platelet-Rich Fibrin Synthetic Bone Graft Enhances Bone Regeneration and Mechanical Strength in Rabbit Femoral Defects: Micro-CT and Biomechanical Study

Journal of Functional Biomaterials
This study evaluated the bone regeneration effect and mechanical properties of “Sticky bone”, a mixture of platelet-rich fibrin (PRF) and synthetic bone grafts (SBGs), in the repair of large femoral bone defects in rabbits.
Yu-Kuan Lin, Hsuan-Wen Wang, Po-Kuei Wu, Chun-Li Lin   +3 more
doaj   +1 more source

A low cost method of testing compression-after-impact strength of composite laminates [PDF]

A method was devised to test the compression strength of composite laminate specimens that are much thinner and wider than other tests require. The specimen can be up to 7.62 cm (3 in) wide and as thin as 1.02 mm (.04 in).
Nettles, Alan T.
core   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Assessment of engineering geological survey quality in Tyumen based on the laboratory soil sample analysis

Архитектура, строительство, транспорт
Carrying out engineering geological surveys is a complex and responsible process. The reliability and safety of design solutions depend on the quality of their execution.
R. V. Melnikov, Z. A. Kosinova, D. V. Rachkov   +2 more
doaj   +1 more source

Compressed/reconstructed test images for CRAF/Cassini [PDF]

A set of compressed, then reconstructed, test images submitted to the Comet Rendezvous Asteroid Flyby (CRAF)/Cassini project is presented as part of its evaluation of near lossless high compression algorithms for representing image data. A total of seven
Arnold, S., Cheung, K.-M., Dolinar, S., Onyszchuk, I., Pollara, F.   +4 more
core   +1 more source