Results 51 to 60 of about 7,612,198 (301)
Compression of Open-Cell Aluminium
Engineering Transactions, 2016 The paper presents compression test results of self-made open-cell aluminium which was produced by the investment casting method. Two groups of samples were studied: prototype samples containing some structural imperfections (apparent density 0.485 g/cm3)
Piotr KASZA +4 more
doaj +1 more source
WEAR AND MECHANICAL STRENGTH OF EPOXY FILLED BY ALUMINIUM OXIDE NANOPARTICLES [PDF]
Journal of the Egyptian Society of Tribology, 2018 This study proposes polymeric dies capable of producing aluminum sheets that will withstand wear and compressive stresses. The wear behavior and compressive strength of the proposed epoxy matrix composites filled by aluminum oxide (Al2O3) nanoparticles ...
A. H. Badran
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Engineering Transactions, 2017 Additive manufacturing is a very fast developing field of research and many parts with complicated geometry are now made using 3D printing. The injection molding, casting, milling and other processes have some limitations and low volume of production ...
Paweł BAJERSKI, Ryszard PĘCHERSKI
doaj +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Addressing Useless Test Data in Core-Based System-on-a-Chip Test
, 2003 This paper analyzes the test memory requirements for core-based systems-on-a-chips and identifies useless test data as one of the contributors to the total amount of test data.
Gonciari, PT, Al-Hashimi, B, Nicolici, N
core +1 more source