Results 81 to 90 of about 24,275 (291)

Multiple Criteria Decision Making Combined with VRP: A Categorized Bibliographic Study [PDF]

International Journal of Supply and Operations Management, 2015
In this research author reviews references related to the topic of multi criterion (goal programming, multiple objective linear and nonlinear programming, bi-criterion programming, Multi Attribute Decision Making, Compromise Programming, Surrogate Worth ...
Yahia Zare Mehrjerdi
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Economic Development Prospects of Forest-Dependent Communities: Analyzing Trade-offs Using a Compromise-Fuzzy Programming Framework [PDF]

, 2008
Many aboriginal communities look to forest resources for short- and long-term employment, adequate timber for mills, an even flow of wood fiber for community stability, and financial returns for economic diversification.
Kooten, G.C., van, G. Cornelis van Kooten, Krcmar, E., Emina Krcmar, van Kooten, G.C.   +4 more
core   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Optimization of Financial Portfolio by Using Nadir Compromising Programming [PDF]

Muṭāli̒āt-i Mudīriyyat-i Ṣan̒atī, 2007
After introducing Markowitz mean-variance model, decision makers (DMs) and financial planners paid much attention to the matter of portfolio selection, so that DMs explain purposes and investment requirements in the frame of multi-objective mathematic ...
Maghsoud Amiri
doaj  

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Optimal Coastal Land Use and Management in Krabi, Thailand: Compromise Programming Approach [PDF]

This paper identifies the optimal options of Krabi’s coastal land use to facilitate the final planning decision. Through compromise programming approach, the optimization models with respect to the weights assigned to two objectives of maximizing the net
Tipparat Pongthanapanich
core   +1 more source

A compromise programming model for site selection of borrow pits [PDF]

, 2008
Road fill construction requires soil for filling low areas; this soil is obtained from temporary mineral workings known as 'borrow pits' (BP). Between a number of possible BPs, the appropriate site should be selected based upon conflicting econo ...
Pantouvakis, J-P, Odysseus George Manoliadis, Manoliadis, OG, John-Paris Pantouvakis   +3 more
core   +1 more source