Results 61 to 70 of about 24,275 (291)
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
[[alternative]]Multiple Objective Programming and Compromise Programming with Weighted Modification [PDF]
, 2014 [[abstract]] 本論文是探討多目標與妥協規劃模式的議題，主要研究多目標演算法及妥協規劃的特性。在多目標演算法中，當多目標為非一致性時， Yu and Zeleney提出的妥協規劃法(compromise programming)，找尋離理想解(ideal solution)最接近的效率解，也就是妥協解(compromise solution)。最終多目標的妥協解是將多目標中賦予適當的權重來決定，但權重與目標並無相關性，實為不足之處 ...
Lin, Wen-Yu, 林文裕
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E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Optimasi alokasi lahan perkebunan menggunakan pendekatan multi kriteria spasial berbasis metode kontinyu [PDF]
, 2013 The proficient planning of land resource becomes a major issue for rural development in Indonesia. It endorses to estimate the capacity of land employing evaluation method.
Ramlan, Andi
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Some Algorithms to Solve a Bi-Objectives Problem for Team Selection
Applied Sciences, 2020 In real life, many problems are instances of combinatorial optimization. Cross-functional team selection is one of the typical issues. The decision-maker has to select solutions among ( k h ) solutions in the decision space, where k
Tung Son Ngo +9 more
doaj +1 more source
Compromise programming with Tchebycheff norm for discrete stochastic orders [PDF]
Annals of Operations Research, 2013 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire +2 more sources
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Compromise solution on multiobjective de novo programming problems: compromise programming application [PDF]
, 2015 De Novo Programlama verilen bir sistemin optimizasyonu yerine, bir optimal sistemin tasarımını gerçekleştirmektedir. Bu tasarım süreci, bütçe kısıtı göz önünde bulundurularak yapılmaktadır.
Türkmen, Ahmet, Umarusman, Nurullah
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Derivation of Optimal Hedging Rules for a Water-supply Reservoir through Compromise Programming [PDF]
, 2010 This study derives optimal hedging rules for simultaneously minimizing short- and long-term shortage characteristics for a water-supply reservoir. Hedging is an effective measure to reduce a high-percentage single period shortage, but at a cost of more ...
蕭政宗; Shiau, Jenq-tzong; Lee, H. C.
core +1 more source