Results 51 to 60 of about 1,058,511 (255)

Analisi dell'allocazione della spesa ambientale: il caso della Campania

Aestimum, 2009
The aim of this paper is to present a methodology for analyzing public decision based on Multicriterial Analysis in a regional case (Campania). The first part is a description at analysis of the environmental aspects, where I propose a DPSR (Driving ...
Tania Salvi
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

On compromise solutions in multiple objective programming [PDF]

, 2018
Compromise solutions, as feasible points as close as possible to the ideal (utopia) point, are important solutions in multiple objective programming. It is known in the literature that each compromise solution is a properly efficient solution if the sum ...
Zamani, Moslem, Majid Soleimani–Damaneh, Soleimani–Damaneh, Majid, Moslem Zamani   +3 more
core   +1 more source

A Compromise Solution for the Fully Fuzzy Multiobjective Linear Programming Problems

IEEE Access, 2018
A new approach is undertaken to solve the fully fuzzy multiobjective linear programming (FFMLP) problem. The coefficients of the objective functions, constraints, right-hand-side parameters, and variables are of the triangular fuzzy number (TrFN)s.
Abdulqader Othman Hamadameen, Nasruddin Hassan   +1 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

The Missouri compromise revisited [PDF]

, 1990
This study concentrates on the period from the introduction of the Tallmadge amendment in February 1819 to the settling of the controversy with the famous Compromise in March 1820.
Robinson, David Paul
core  

Some Algorithms to Solve a Bi-Objectives Problem for Team Selection

Applied Sciences, 2020
In real life, many problems are instances of combinatorial optimization. Cross-functional team selection is one of the typical issues. The decision-maker has to select solutions among ( k h ) solutions in the decision space, where k
Tung Son Ngo, Ngoc Anh Bui, Thi Thuy Tran, Phuong Chi Le, Dinh Chien Bui, The Duy Nguyen, Lac Duong Phan, Quoc Tuan Kieu, Ba Son Nguyen, Son N. Tran   +9 more
doaj   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source