Results 121 to 130 of about 7,854,622 (293)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
The teaching of languages in the Basque Country
Avances en Supervisión Educativa, 2010 Our autonomous region holds two official languages: Castilian (i.e. Spanish) and Euskera (i.e. Basque). Both languages are widely used at school as first languages since the 1980s, from Infant Education to Compulsory Secondary Education and Bachillerato (
Rosa Aliaga Ugarte
doaj
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
We show that the length of compulsory education has a causal impact on regional labour mobility. The analysis is based on a quasi-exogenous staged Norwegian school reform, and register data on the whole population.
Kjell Salvanes +2 more
core
Curriculum connections: lessons from post-compulsory vocational education and training
, 2011 Curriculum, as one of the three educational message systems (with pedagogy and assessment), can be understood as potentially complicit with disconnections and missed opportunities for creating connections in teaching and learning.
Parry, Lindsay +2 more
core +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Were Compulsory Attendance and Child Labor Laws Effective? An Analysis from 1915 to 1939 [PDF]
Secondary schooling experienced incredible growth in the first 40 years of the 20th Century. Was legislation on compulsory attendance and child labor responsible for this growth?
Adriana Lleras-Muney
core
Multidisciplinary Journal of School Education, 2018 The Amendment to the Education Act has introduced compulsory preschool education for children from the age of 5 and an obligation for the parents to register their child for such compulsory education.
Radmila Burkovičová
doaj