Results 111 to 120 of about 8,231,669 (291)
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
The Effect of Compulsory Schooling on Health - Evidence from Biomarkers [PDF]
Using data from the Health Survey for England and the English Longitudinal Study on Ageing, we estimate the causal effect of schooling on health. Identification comes from two nation wide increases in British compulsory school leaving age in 1947 and ...
Steffen Reinhold +2 more
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
'Sorry to have kept you waiting so long, Mr Macfarlane': Further education after the Coalition [PDF]
, 2013 This chapter focuses on the further education (FE) sector in England. Initially it gives an overview of the ‘condition’ of the FE sector and summarises of some of the main characteristics of the current Government’s approach to further education.
Simmons, Robin
core +2 more sources
Post-Compulsory Education in Teenagers and Young Adults Treated for Brain Tumors in Childhood: A Swedish Nationwide Registry-Based Study. [PDF]
Cancers (Basel), 2022 Lönnerblad M +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
We show that the length of compulsory education has a causal impact on regional labour mobility. The analysis is based on a quasi-exogenous staged Norwegian school reform, and register data on the whole population.
Kjell Salvanes +2 more
core
Full-information item bifactor model for mathematical ability assessment in Chinese compulsory education quality monitoring. [PDF]
Front Psychol, 2022 Meng X, Yang T, Shi N, Xin T.
europepmc +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
International Journal of Adolescence and YouthAccess to post-compulsory education remains highly unequal for socioeconomically vulnerable students. This qualitative case study examines the factors enabling successful educational transitions in a school located in one of Spain's most disadvantaged ...
Teresa Morlà-Folch +2 more
doaj +1 more source