Results 81 to 90 of about 7,854,622 (293)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Compulsory Education and Teenage Motherhood [PDF]

, 2017
Can education policy reduce the incidence of teenage motherhood? This paper uses data from the largest UK household-level survey to investigate the impact of a change in legislation, which increased the duration of compulsory schooling, on the timing of ...
Wilson, Tanya
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

La scolarité obligatoire en Algérie : ambitions et défis

Revue Internationale d’Éducation de Sèvres, 2016
Algerian schooling promotes an educational project set out in the framework law on national education of 23 January 2008. On leaving compulsory education, the learner should have attained a level of mastery of basic languages in order to continue ...
Mina Tounsi
doaj   +1 more source

Nutrition improvement program for rural compulsory education students and individual health. [PDF]

Front Public Health, 2022
Liang Y, Chen X, Zhao C, Jiang S.
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Curriculum discourses in post-compulsory education: a case study on the introduction of 'Higher Still' in Scotland

, 2003
The paper questions the current importance given in the post-compulsory literature to curriculum planning models. In particular, the writer draws attention to how curriculum discourses promote an overly rational and simplistic view of systemic education ...
Canning, Roy
core   +1 more source

Éducation gratuite et obligatoire : une étude sur le cas du Libéria

Revue Internationale d’Éducation de Sèvres, 2016
This article examines what Liberian schools are teaching to students under the free, compulsory basic education policy. The authors conducted qualitative research among sixty stakeholders in education.
Charles Gbollie, Emmanuel Boone Waydon, Joseph Bernard   +2 more
doaj   +1 more source

Inclusive Culture in Compulsory Education Centers: Values, Participation and Teachers' Perceptions. [PDF]

Children (Basel), 2022
Valle-Flórez RE, de Caso Fuertes AM, Baelo R, Marcos-Santiago R.   +3 more
europepmc   +1 more source