Results 71 to 80 of about 91,439 (301)
Understanding the pharmaceutical patent system in Spain and Europe: a perspective from the need to take its protection-access tradeoff seriously [PDF]
, 2020 As a result of the doctoral research developed by the main author (Vargas-Chaves, 2017), it was identified the evolution and perspectives of the pharmaceutical patent in the international trade system, as well as it future legal research needs in this ...
López-Oliva, José +1 more
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Os Contratos de Licenciamento e a Eficiência Técnica dos Setores Industriais Brasileiros: Uma Análise à Luz do Método de Fronteira Estocástica e da Análise Envoltória de Dados (DEA) [PDF]
The paper addresses the relationship between licenses and technical efficiency in a set of Brazilian industrial sectors. The main hypothesis is that licenses are negatively related with technical efficiency.
André Luis Rossi de Oliveira +2 more
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No pills for poor people? Understanding the disembowelment of India’s patent regime [PDF]
, 2005 The recent amendment to the Patent Act, 1970 brings India into full compliance with its obligations under the TRIPs Agreement, in particular allowing for product patents in the area of pharmaceuticals and agrichemicals.
Rangnekar, Dwijen
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Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Korea, the Pharmaceutical Industry and Non-Commercial Use in the TRIPS Agreement [PDF]
In 2002, a number of associations requested the Korean Patent Office to issue a compulsory license for the manufacture of a drug under the Korean patent provision which permits the issue of compulsory licensing for public non-commercial use.
Shanker, Daya
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Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
La santé globale : biopolitique en territoires
Revue Francophone sur la Santé et les Territoires, 2018 The 1851 Paris Meeting to build cooperation for health between nations heralded the governance of international health concerning the scale of the nation-state and the organization of the interrelations between them.
Alain Vaguet
doaj +1 more source
Protecting Intellectual Property in the Developing World: Next Stop—Thailand [PDF]
, 2006 This iBrief examines the U.S. strategy for strengthening the protection of intellectual property rights (IPRs) in Southeast Asia through the use of free trade agreements (FTAs). After briefly examining the U.S.
Arnold, Cortney M.
core +1 more source